<div class="csl-bib-body">
<div class="csl-entry">Rienda, I., Moro, E., Pérez Rubio, Á., Trullenque Juan, R., Pérez-Guaita, D., Lendl, B., Kuligowski, J., Castell, J. V., Pérez Rojas, J., Pareja, E., & Quintás, G. (2023). Comparing the direct assessment of steatosis in liver explants with mid- and near-infrared vibrational spectroscopy, prior to organ transplantation. <i>Analyst</i>, <i>148</i>(17), 3986–3991. https://doi.org/10.1039/d3an01184d</div>
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dc.identifier.issn
0003-2654
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dc.identifier.uri
http://hdl.handle.net/20.500.12708/211724
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dc.description.abstract
A fast and accurate assessment of liver steatosis is crucial during liver transplantation surgery as it can negatively impact its success. Recent research has shown that near-infrared (NIR) and attenuated total reflectance-Fourier transform mid-infrared (ATR-FTIR) spectroscopy could be used as real-time quantitative tools to assess steatosis during abdominal surgery. Here, in the frame of a clinical study, we explore the performance of NIR and ATR-FTIR spectroscopy for the direct assessment of steatosis in liver tissues. Results show that both NIR and ATR-FTIR spectroscopy are able to quantify the % of steatosis with cross-validation errors of 1.4 and 1.6%, respectively. Furthermore, the two portable instruments used both provided results within seconds and can be placed inside an operating room evidencing the potential of IR spectroscopy for initial characterization of grafts in liver transplantation surgery. We also evaluated the complementarity of the spectral ranges through correlation spectroscopy.
en
dc.language.iso
en
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dc.publisher
ROYAL SOC CHEMISTRY
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dc.relation.ispartof
Analyst
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dc.subject
Humans
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dc.subject
Spectroscopy
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dc.subject
Near-Infrared
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dc.subject
Fatty Liver
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dc.subject
Organ Transplantation
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dc.subject
Fourier Transform Infrared
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dc.title
Comparing the direct assessment of steatosis in liver explants with mid- and near-infrared vibrational spectroscopy, prior to organ transplantation
