<div class="csl-bib-body">
<div class="csl-entry">Burger, I., Schmal, M., Peikert, K., Fourtis, L., Suster, C., Stanetty, C., Schnalzer, D., Hufnagel, B., Böttcher, T., Birner-Gruenberger, R., Mach, R. L., Mach-Aigner, A. R., Schittmayer-Schantl, M., & Zimmermann, C. (2025). Discovery of the antifungal compound ilicicolin K through genetic activation of the ilicicolin biosynthetic pathway in Trichoderma reesei. <i>BIOTECHNOLOGY FOR BIOFUELS AND BIOPRODUCTS</i>, <i>18</i>(1), Article 32. https://doi.org/10.1186/s13068-025-02628-3</div>
</div>
-
dc.identifier.issn
2731-3654
-
dc.identifier.uri
http://hdl.handle.net/20.500.12708/213831
-
dc.description.abstract
Given the global rise in antimicrobial resistance, the discovery of novel antimicrobial agents and production processes thereof are of utmost importance. To this end we have activated the gene cluster encoding for the biosynthesis of the potent antifungal compound ilicicolin H in the fungus Trichoderma reesei. While the biosynthetic gene cluster (BGC) is silent under standard cultivation conditions, we achieved BGC activation by genetically overexpressing the transcription factor TriliR.
en
dc.description.sponsorship
FWF - Österr. Wissenschaftsfonds
-
dc.language.iso
en
-
dc.publisher
BMC
-
dc.relation.ispartof
BIOTECHNOLOGY FOR BIOFUELS AND BIOPRODUCTS
-
dc.subject
Antifungal agents
en
dc.subject
Fungi
en
dc.subject
Multi-omics
en
dc.subject
Natural products
en
dc.subject
Pathway engineering
en
dc.title
Discovery of the antifungal compound ilicicolin K through genetic activation of the ilicicolin biosynthetic pathway in Trichoderma reesei
en
dc.type
Article
en
dc.type
Artikel
de
dc.identifier.pmid
40069746
-
dc.contributor.affiliation
TU Wien, Austria
-
dc.contributor.affiliation
University of Vienna, Austria
-
dc.contributor.affiliation
University of Vienna, Austria
-
dc.relation.grantno
P 34036-B
-
dc.type.category
Original Research Article
-
tuw.container.volume
18
-
tuw.container.issue
1
-
tuw.journal.peerreviewed
true
-
tuw.peerreviewed
true
-
tuw.project.title
Identifizierung und Charakterisierung von RiPPs aus Pilzen
-
tuw.researchTopic.id
M6
-
tuw.researchTopic.name
Biological and Bioactive Materials
-
tuw.researchTopic.value
100
-
dcterms.isPartOf.title
BIOTECHNOLOGY FOR BIOFUELS AND BIOPRODUCTS
-
tuw.publication.orgunit
E166-05-1 - Forschungsgruppe Synthetische Biologie und Molekulare Biotechnologie
