<div class="csl-bib-body">
<div class="csl-entry">Vasconez Martinez, M. G., Rothbauer, M., Rosety, I., Purer, S. K., Fink, J., & Wartmann, D. (2025, June 12). <i>Body-on-a-chip towards neurotoxicity monitoring in environmental safety and CBRN applications</i> [Poster Presentation]. MPS World Summit 2025, Brussels, Belgium. http://hdl.handle.net/20.500.12708/221380</div>
</div>
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dc.identifier.uri
http://hdl.handle.net/20.500.12708/221380
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dc.description.abstract
Organophosphates (OP) are prevalent components in pesticides and chemical weapons, such as Malathion or Sarin gas [1]. As Acetylcholine esterase inhibitors, exposure to OPs has been proven to be fatal or to cause severe neurological disorders [1,2]. Therefore, regular environmental monitoring to detect OP concentrations is essential in agricultural applications and needed for the military sector to ensure the safety of personnel and civilian populations [2,3]. State-of-the-art analytical detection methods such as mass spectroscopy and liquid chromatography require time-consuming pre-treatments, costly reagents and are not suited for in-field usage [1,3]. Furthermore, current detection methos need to be calibrated, are specific to a single toxic compound and fail to account for the complex interactions within the human body.
There is an urgent need for enhanced methods to assess environmental organophosphate neurotoxicity without endangering human or animal lives [2]. This study developed a multi-organ microphysiological system for in-field deployment capable of acute neurotoxicity evaluation.
This Body-On-A-Chip model consists of five interconnected organ models and two micropumps for increases organ-to-organ interactions and media distribution. The model mimics the pathway of OPs through the skin into the body where it interacts with the liver, kidneys and the vascular system before breaching the blood brain barrier and finally arriving at the midbrain.
In order to detect the damage severity of a tested compound, the system analyses the oxygen consumption in the area around the midbrain model and relates it to its viability.
[1] Vasconez M., M.G., Parato, N., Schobesberger, S., et al. (2024). Sens. Actuator B-Chem. 408, 135568, doi: 10.1016/j.snb.2024.135568
[2] Dorandeu, F., Singer, C., Chatfield, S., et al. (2023). Eur J Emerg Med. 6:402-407 doi:10.1097/MEJ.0000000000001060
[3] Bhattu, M., Vermaa, M., Kathuria, D. (2021), Anal. Methods 13, doi:4390-4428 10.1039/d1ay01186c
en
dc.description.sponsorship
FFG - Österr. Forschungsförderungs- gesellschaft mbH
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dc.language.iso
en
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dc.subject
body-on-a-chip
en
dc.subject
Toxicology
en
dc.title
Body-on-a-chip towards neurotoxicity monitoring in environmental safety and CBRN applications
en
dc.type
Presentation
en
dc.type
Vortrag
de
dc.contributor.affiliation
Organo Therapeutics, Luxembourg
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dc.contributor.affiliation
Lorenz Boltzman Institute, Austria
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dc.contributor.affiliation
Joanneum Research, Austria
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dc.contributor.affiliation
DENZ Biomedical, Austria
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dc.relation.grantno
895153
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dc.type.category
Poster Presentation
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tuw.project.title
Simulation von Neurottoxintoxizität via Hautaufnahmeroute mittels einem Body-on-a-Chip-Verfahrens
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tuw.researchTopic.id
M6
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tuw.researchTopic.id
C6
-
tuw.researchTopic.id
X1
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tuw.researchTopic.name
Biological and Bioactive Materials
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tuw.researchTopic.name
Modeling and Simulation
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tuw.researchTopic.name
Beyond TUW-research focus
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tuw.researchTopic.value
30
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tuw.researchTopic.value
10
-
tuw.researchTopic.value
60
-
tuw.publication.orgunit
E163-03-1 - Forschungsgruppe Cell Chip
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tuw.author.orcid
0009-0001-3841-209X
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tuw.author.orcid
0000-0001-9118-6995
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tuw.event.name
MPS World Summit 2025
en
tuw.event.startdate
09-06-2025
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tuw.event.enddate
13-06-2025
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tuw.event.online
On Site
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tuw.event.type
Event for scientific audience
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tuw.event.place
Brussels
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tuw.event.country
BE
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tuw.event.presenter
Vasconez Martinez, Mateo Gabriel
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wb.sciencebranch
Chemische Verfahrenstechnik
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wb.sciencebranch
Pharmazie, Pharmakologie, Toxikologie
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wb.sciencebranch
Medizinische Biochemie, Humangenetik
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wb.sciencebranch.oefos
2040
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wb.sciencebranch.oefos
3012
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wb.sciencebranch.oefos
3013
-
wb.sciencebranch.value
20
-
wb.sciencebranch.value
40
-
wb.sciencebranch.value
40
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item.openairetype
conference poster not in proceedings
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item.openairecristype
http://purl.org/coar/resource_type/c_18co
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item.cerifentitytype
Publications
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item.languageiso639-1
en
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item.grantfulltext
none
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item.fulltext
no Fulltext
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crisitem.author.dept
E163-03-1 - Forschungsgruppe Cell Chip
-
crisitem.author.dept
E163-03-1 - Forschungsgruppe Cell Chip
-
crisitem.author.dept
Organo Therapeutics, Luxembourg
-
crisitem.author.dept
Lorenz Boltzman Institute, Austria
-
crisitem.author.dept
Joanneum Research, Austria
-
crisitem.author.dept
DENZ Biomedical, Austria
-
crisitem.author.orcid
0009-0001-3841-209X
-
crisitem.author.orcid
0000-0001-9118-6995
-
crisitem.author.parentorg
E163-03 - Forschungsbereich Organische und Biologische Chemie
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crisitem.author.parentorg
E163-03 - Forschungsbereich Organische und Biologische Chemie
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crisitem.project.funder
FFG - Österr. Forschungsförderungs- gesellschaft mbH
