<div class="csl-bib-body">
<div class="csl-entry">Garcia de Otazo Hernandez, D., Seltenhammer, I. L., Sabatino, G., Ioannou, A., Untersmayr, E., & Ret, D. (2025, June 18). <i>Elucidating post-viral fatigue sydrome: Conserving sialic acid on O-Glycans</i> [Poster Presentation]. TCH Science Days 2025, Wien, Austria.</div>
</div>
-
dc.identifier.uri
http://hdl.handle.net/20.500.12708/221580
-
dc.description.abstract
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a complex inflammatory condition characterized by chronic fatigue, post-exertional malaise, and immune dysregulation whose underlying mechanisms remain poorly understood. Glycosylation, the process of attaching glycans to proteins and lipids, plays a crucial role in immune cell communication and inflammation. As sialic acid has great importance in autoimmune and inflammatory diseases, the focus was directed towards a controlled release and labelling reaction with all conditions avoiding acidic hydrolysis of sialic acid. O-glycans from blood sera and purified antibodies where methyl amidated to stabilize sialic acid. The release reaction proceeds via non-reductive β-elimination and subsequent labelling with a fluorescent compound in conditions able to conserve sialic acid in antennary position. The O-glycan profiles are analyzed by HPLC with fluorescence and MALDI mass spectrometry. O-glycosylation profiles with intact sialylation of ME/CFS patients and healthy controls reveal an altered O-Glycan pattern which may contribute to the chronic inflammatory state observed in ME/CFS.
en
dc.description.sponsorship
WWTF Wiener Wissenschafts-, Forschu und Technologiefonds
-
dc.language.iso
en
-
dc.subject
Sialic acid
en
dc.subject
O-Glycosylation
en
dc.subject
Fluorescence
en
dc.subject
Chromatography
en
dc.subject
ME/CFS
en
dc.title
Elucidating post-viral fatigue sydrome: Conserving sialic acid on O-Glycans
en
dc.type
Presentation
en
dc.type
Vortrag
de
dc.contributor.affiliation
TU Wien, Austria
-
dc.contributor.affiliation
TU Wien, Austria
-
dc.contributor.affiliation
Medical University of Vienna, Austria
-
dc.contributor.affiliation
Medical University of Vienna, Austria
-
dc.relation.grantno
ME-CFS24-016
-
dc.type.category
Poster Presentation
-
tuw.project.title
Exploring the Glycome: Identifying Glycosylation-Related Biomarkers in Chronic Fatigue Syndrome
-
tuw.researchTopic.id
M6
-
tuw.researchTopic.name
Biological and Bioactive Materials
-
tuw.researchTopic.value
100
-
tuw.publication.orgunit
E163-02-1 - Forschungsgruppe Polymerchemie und Technologie
-
tuw.author.orcid
0000-0003-0126-3868
-
tuw.author.orcid
0000-0002-1963-499X
-
tuw.author.orcid
0000-0002-7461-0923
-
tuw.event.name
TCH Science Days 2025
en
tuw.event.startdate
17-06-2025
-
tuw.event.enddate
18-06-2025
-
tuw.event.online
On Site
-
tuw.event.type
Event for scientific audience
-
tuw.event.place
Wien
-
tuw.event.country
AT
-
tuw.event.presenter
Garcia de Otazo Hernandez, Daniel
-
tuw.event.track
Single Track
-
wb.sciencebranch
Chemie
-
wb.sciencebranch
Pharmazie, Pharmakologie, Toxikologie
-
wb.sciencebranch
Medizinische Biochemie, Humangenetik
-
wb.sciencebranch.oefos
1040
-
wb.sciencebranch.oefos
3012
-
wb.sciencebranch.oefos
3013
-
wb.sciencebranch.value
60
-
wb.sciencebranch.value
20
-
wb.sciencebranch.value
20
-
item.openairetype
conference poster not in proceedings
-
item.openairecristype
http://purl.org/coar/resource_type/c_18co
-
item.cerifentitytype
Publications
-
item.languageiso639-1
en
-
item.grantfulltext
restricted
-
item.fulltext
no Fulltext
-
crisitem.author.dept
E163-02-1 - Forschungsgruppe Polymerchemie und Technologie
-
crisitem.author.dept
TU Wien, Austria
-
crisitem.author.dept
E163-02-1 - Forschungsgruppe Polymerchemie und Technologie
-
crisitem.author.dept
Medical University of Vienna, Austria
-
crisitem.author.dept
E163-02-1 - Forschungsgruppe Polymerchemie und Technologie
