This study investigates the oxidation properties of group IV to VI transition metal carbides (TMCs), specifically titanium, zirconium, hafnium, tantalum and tungsten carbide, which are known for their exceptional thermal stability and mechanical strength, making them ideal for high temperature applications in the aerospace, automotive and tooling industries. Despite their advantageous properties, TMCs face significant limitations due to their poor oxidation resistance. To address this challenge, we are employing a combinatorial PVD approach to investigate different alloying strategies – focusing on strong oxide formers such as Si and disilicides – leading to the formation of ternary and quaternary TMCs to improve their performance in high-temperature, oxygen-rich environments. Density Functional Theory calculations are used to establish a theoretical background for the phase formation of these novel material classes, which is subsequently validated by structural analysis. In a second step, the oxidation resistance of these materials is tested at temperatures up to 1500°C. The scale formations were analyzed using high-resolution characterization techniques. This comprehensive material screening approach aims to advance and promote the applicability of TMCs under extreme conditions.