A versatile solvent-free Wittig olefination of sugars via mechanochemistry is reported, tolerating common protecting groups as well as unprotected substrates. The method efficiently delivers structurally diverse olefins under mild and solvent-free conditions. Subsequent solvent-free late-stage modifications of the olefins demonstrate the potential of the methodology for greener sugar-based synthetic sequences.
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dc.description.sponsorship
FWF - Österr. Wissenschaftsfonds
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dc.language.iso
en
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dc.publisher
WILEY-V C H VERLAG GMBH
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dc.relation.ispartof
ChemSusChem
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dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
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dc.subject
Wittig reaction
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dc.subject
ball milling
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dc.subject
carbohydrate
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dc.subject
mechanochemistry
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dc.title
Mechanochemistry Enables Rapid and Solvent-Free Wittig Reactions on Sugars