<div class="csl-bib-body">
<div class="csl-entry">Scheibelreiter, V., Wutscher, M., Csechala, L., Bornscheuer, U., Stanetty, C., & Rudroff, F. (2025, June 29). <i>Cytochrome p450 bm3 as a novel approach for cyclic ether functionalization</i> [Poster Presentation]. BIOTRANS 2025 : 17th International Symposium on Biocatalysis and Biotransformations, Basel, Switzerland. https://doi.org/10.34726/11699</div>
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dc.identifier.uri
http://hdl.handle.net/20.500.12708/223993
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dc.identifier.uri
https://doi.org/10.34726/11699
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dc.description.abstract
The enzymatic oxidation of α-CH bonds in cyclic ethers presents a largely unexplored route for the biocatalytic synthesis of aldehydes and lactones. These products are valuable intermediates in the synthesis of fine chemicals, pharmaceuticals, and materials. Here, we demonstrate that the cytochrome P450 BM3 mutant 9-10A F87I(1) catalyzes the selective oxidation of non-activated cyclic ethers. Preliminary results with menthol-derived ethers and simple hydrocarbon ethers indicate regioselective oxidation, establishing a new enzymatic strategy for ether functionalization. This work broadens the scope of enzymatic CH-activation and underscores the potential of engineered P450s for novel oxidative transformations. References (1) J. C. Lewis, S. Bastian, C. S. Bennett, Y. Fu, Y. Mitsude, M. M. Chen, w. A. Greenberg, C. Wong, F. H. Arnold, Proc Natl Acad Sci U S A 2009, 106, 16550-16555.
en
dc.description.sponsorship
FWF - Österr. Wissenschaftsfonds
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dc.language.iso
en
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dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
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dc.subject
Biocatalysis
en
dc.subject
Monooxygenases
en
dc.title
Cytochrome p450 bm3 as a novel approach for cyclic ether functionalization
en
dc.type
Presentation
en
dc.type
Vortrag
de
dc.rights.license
Creative Commons Namensnennung 4.0 International
de
dc.rights.license
Creative Commons Attribution 4.0 International
en
dc.identifier.doi
10.34726/11699
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dc.contributor.affiliation
Universität Greifswald, Germany
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dc.contributor.affiliation
Universität Greifswald, Germany
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dc.relation.grantno
I 5877
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dc.type.category
Poster Presentation
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tuw.project.title
Biokatalytische Dealkylierung für die organische Synthese
