<div class="csl-bib-body">
<div class="csl-entry">Moroni, G., & Bica-Schröder, K. (2025, April 3). <i>CO-Driven Sulfoximinocarbonylation of Aryl Halides in Continuous Flow</i> [Poster Presentation]. Flow Chemistry Europe : Augmenting chemistry with sustainable flow processes (FCE-25), Malaga, Spain. https://doi.org/10.34726/11727</div>
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dc.identifier.uri
http://hdl.handle.net/20.500.12708/224352
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dc.identifier.uri
https://doi.org/10.34726/11727
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dc.description.abstract
Carbonylation reactions play a crucial role in organic and industrial chemistry, enabling the introduction of carbonyl groups into organic substrates using carbon monoxide (CO). While CO is cost-effective and atom-efficient reagent, its toxicity and high-pressure handling present significant challenges in traditional batch processes. In recent years, flow chemistry has revolutionized these transformations, offering enhanced efficiency, safety, and precise control of reaction parameters.
Sulfoximines are valuable scaffold in pharmaceutical, agricultural, and organic chemistry as chiral auxiliars and intermediates. Despite their synthetic potential, previous approaches often rely on toxic reagents, excessive oxidants, and tedious purification steps, leading to low conversions and undesirable by-products.
Here, we report a continuous flow protocol for the N-aroylation of different functionalized aryl halides with sulfoximines under CO pressure using a palladium-based catalyst, a base, and a ligand. Comprehensive screening of organic bases in batch mode allowed to identify optimal conditions, which were then translated into a flow system operating at 80 °C and 6 bar for 40 minutes. This innovative strategy provides rapid reactions, high selectivity, and good to excellent yields (up to 90%) across a small library, demonstrating the advantages of continuous flow technology in carbonylation chemistry.
en
dc.language.iso
en
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dc.rights.uri
http://rightsstatements.org/vocab/InC/1.0/
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dc.subject
flow chemistry
en
dc.subject
CO
en
dc.subject
carbonylation reaction
en
dc.subject
sulfoximinocarbonylation
en
dc.title
CO-Driven Sulfoximinocarbonylation of Aryl Halides in Continuous Flow
en
dc.type
Presentation
en
dc.type
Vortrag
de
dc.rights.license
Urheberrechtsschutz
de
dc.rights.license
In Copyright
en
dc.identifier.doi
10.34726/11727
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dc.type.category
Poster Presentation
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tuw.researchTopic.id
X1
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tuw.researchTopic.name
Beyond TUW-research focus
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tuw.researchTopic.value
100
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tuw.publication.orgunit
E163-03-5 - Forschungsgruppe Nachhaltige organische Synthese und Katalyse
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tuw.publication.orgunit
E056-09 - Fachbereich CO2 Refinery
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tuw.author.orcid
0000-0002-2515-9873
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dc.rights.identifier
Urheberrechtsschutz
de
dc.rights.identifier
In Copyright
en
tuw.event.name
Flow Chemistry Europe : Augmenting chemistry with sustainable flow processes (FCE-25)
en
tuw.event.startdate
03-04-2025
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tuw.event.enddate
04-04-2025
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tuw.event.online
On Site
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tuw.event.type
Event for scientific audience
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tuw.event.place
Malaga
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tuw.event.country
ES
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tuw.event.presenter
Moroni, Giada
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wb.sciencebranch
Chemie
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wb.sciencebranch
Chemische Verfahrenstechnik
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wb.sciencebranch
Pharmazie, Pharmakologie, Toxikologie
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wb.sciencebranch.oefos
1040
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wb.sciencebranch.oefos
2040
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wb.sciencebranch.oefos
3012
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wb.sciencebranch.value
60
-
wb.sciencebranch.value
20
-
wb.sciencebranch.value
20
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item.mimetype
application/pdf
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item.openairetype
conference poster not in proceedings
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item.openairecristype
http://purl.org/coar/resource_type/c_18co
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item.cerifentitytype
Publications
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item.languageiso639-1
en
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item.openaccessfulltext
Open Access
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item.grantfulltext
open
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item.fulltext
with Fulltext
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crisitem.author.dept
E163-03-5 - Forschungsgruppe Nachhaltige organische Synthese und Katalyse
-
crisitem.author.dept
E163-03-5 - Forschungsgruppe Nachhaltige organische Synthese und Katalyse
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crisitem.author.orcid
0000-0002-2515-9873
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crisitem.author.parentorg
E163-03 - Forschungsbereich Organische und Biologische Chemie
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crisitem.author.parentorg
E163-03 - Forschungsbereich Organische und Biologische Chemie
