reposiTUm: Expanding Iontronic Drug Delivery Via Bioorthogonal Click–to

DC Field

Value

Language

dc.contributor.author

Hecko, Sebastian

dc.contributor.author

Vleugels, Marle

dc.contributor.author

Bayer, Christian

dc.contributor.author

Byun, Donghak

dc.contributor.author

Moa E. Hörberg

dc.contributor.author

Poremba, Nikolaus

dc.contributor.author

Boukraa, Rassen

dc.contributor.author

Keppel, Patrick

dc.contributor.author

Löffler, Andreas

dc.contributor.author

Kuba, W.

dc.contributor.author

Saarela Unemo, Helena

dc.contributor.author

Bernacka-Wojcik, Iwona

dc.contributor.author

Arbring Sjöström, Theresia

dc.contributor.author

Berggren, Magnus

dc.contributor.author

Simon, Daniel

dc.contributor.author

Schindl, Rainer

dc.contributor.author

Waldherr, Linda

dc.contributor.author

Mikula, Hannes

dc.contributor.author

Bintinger, Johannes

dc.date.accessioned

2026-01-14T16:48:32Z

dc.date.available

2026-01-14T16:48:32Z

dc.date.issued

2025-10-08

dc.identifier.citation

<div class="csl-bib-body"> <div class="csl-entry">Hecko, S., Vleugels, M., Bayer, C., Byun, D., Moa E. Hörberg, Poremba, N., Boukraa, R., Keppel, P., Löffler, A., Kuba, W., Saarela Unemo, H., Bernacka-Wojcik, I., Arbring Sjöström, T., Berggren, M., Simon, D., Schindl, R., Waldherr, L., Mikula, H., & Bintinger, J. (2025, October 8). <i>Expanding Iontronic Drug Delivery Via Bioorthogonal Click–to–Release (C2R)</i> [Poster Presentation]. ChemBioParis 2025, France. http://hdl.handle.net/20.500.12708/224416</div> </div>

dc.identifier.uri

http://hdl.handle.net/20.500.12708/224416

dc.description.abstract

Iontronic devices or “ion pumps” enable electronically controlled delivery or of molecules through ion–selective membranes with exceptional spatiotemporal resolution. This transport occurs without any fluid movement or mechanical components, making it particularly well suited for precise and reliable therapeutic release. However, this transport mechanism is inherently limited to charged, low molecular weight (<500 g/mol) and electrochemically stable compounds. To overcome these constraints, we present BioSWITCH, a hybrid delivery strategy that decouples molecular transport from therapeutic activation by integrating iontronic delivery with bioorthogonal click–to–release (C2R) chemistry. In this system, charged aminoethyl tetrazines are delivered iontronically to a localized prodrug reservoir, where they undergo an inverse electron demand Diels-Alder (IEDDA) reaction with trans–cyclooctene (cTCO) caged compounds. This enables precise, bioorthogonal activation of therapeutic payloads, irrespective of their molecular size or charge. We demonstrated programmable tetrazine delivery over multiple days using periodic device operation and subsequently validated the concept through activation of potent anti mitotic agent Combretastatin A-4 (CA4). Iontronic tetrazine delivery activated the bound CA4-prodrug, resulting in antiproliferative effects in glioblastoma cell models. Building on these results, we also achieved controlled release of the protein bovine serum albumin (BSA), demonstrating the platform’s ability to overcome the size limitations of conventional iontronic systems. The amount of released protein scaled linearly with the duration of tetrazine delivery, enabling precise, time dependent control over macromolecular release. Together, these results establish BioSWITCH as a novel approach that extends the capabilities of iontronic pumps toward the controlled release of both small molecules and macromolecular therapeutics.

dc.description.sponsorship

European Commission

dc.description.sponsorship

European Commission

dc.description.sponsorship

European Commission

dc.language.iso

dc.subject

Bioorthogonal Chemistry

dc.subject

Iontronic Delivery

dc.subject

Drug Delivery

dc.subject

Electroceuticals

dc.title

Expanding Iontronic Drug Delivery Via Bioorthogonal Click–to–Release (C2R)

dc.type

Presentation

dc.type

Vortrag

dc.contributor.affiliation

Linköping University, Sweden

dc.contributor.affiliation

Medical University of Graz, Austria

dc.contributor.affiliation

Linköping University, Sweden

dc.contributor.affiliation

Linköping University, Sweden

dc.contributor.affiliation

Linköping University, Sweden

dc.contributor.affiliation

Linköping University, Sweden

dc.contributor.affiliation

Linköping University, Sweden

dc.contributor.affiliation

Linköping University, Sweden

dc.contributor.affiliation

Linköping University, Sweden

dc.contributor.affiliation

Medical University of Graz, Austria

dc.contributor.affiliation

Medical University of Graz, Austria

dc.relation.grantno

101099963

dc.relation.grantno

101117736

dc.relation.grantno

101042881

dc.type.category

Poster Presentation

tuw.project.title

Bioorthogonal Implantable Iontronic Switch to Temporally Control the Local Release of Chemotherapeutics

tuw.project.title

Bioorthogonale iontronische Chemie: Wirkstoff-Transport mit elektronischer Präzision

tuw.project.title

Bioorthogonal Cascade-Targeting: Directing Drugs into Cells with Molecular Precision

tuw.researchinfrastructure

Zentrum für Kernspinresonanzspektroskopie

tuw.researchTopic.id

tuw.researchTopic.name

Biological and Bioactive Materials

tuw.researchTopic.value

100

tuw.publication.orgunit

E163-03-2 - Forschungsgruppe Molekulare Chemie und Chemische Biologie

tuw.author.orcid

0000-0002-6210-4425

tuw.author.orcid

0000-0002-6686-3568

tuw.author.orcid

0009-0009-2470-2617

tuw.author.orcid

0000-0001-5799-7858

tuw.author.orcid

0000-0002-2119-9755

tuw.author.orcid

0009-0006-5206-469X

tuw.author.orcid

0000-0001-6910-6813

tuw.author.orcid

0009-0001-7662-6021

tuw.author.orcid

0000-0002-7135-8275

tuw.author.orcid

0000-0001-7729-0251

tuw.author.orcid

0000-0001-5154-0291

tuw.author.orcid

0000-0002-2799-3490

tuw.author.orcid

0000-0001-9817-1358

tuw.author.orcid

0000-0002-9218-9722

tuw.author.orcid

0000-0002-6397-4254

tuw.event.name

ChemBioParis 2025

dc.description.sponsorshipexternal

Austrian Science Fund (FWF)

dc.description.sponsorshipexternal

Austrian Science Fund (FWF)

dc.description.sponsorshipexternal

Austrian Science Fund (FWF)

dc.relation.grantnoexternal

10.55776/J4304

dc.relation.grantnoexternal

10.55776/I4623

dc.relation.grantnoexternal

10.55776/Y1443

tuw.event.startdate

06-10-2025

tuw.event.enddate

09-10-2025

tuw.event.online

On Site

tuw.event.type

Event for scientific audience

tuw.event.country

tuw.event.presenter

Hecko, Sebastian

tuw.event.track

Single Track

wb.sciencebranch

Chemie

wb.sciencebranch

Pharmazie, Pharmakologie, Toxikologie

wb.sciencebranch

Elektrotechnik, Elektronik, Informationstechnik

wb.sciencebranch.oefos

1040

wb.sciencebranch.oefos

3012

wb.sciencebranch.oefos

2020

wb.sciencebranch.value

item.openairetype

conference poster not in proceedings

item.openairecristype

http://purl.org/coar/resource_type/c_18co

item.cerifentitytype

Publications

item.languageiso639-1

item.grantfulltext

restricted

item.fulltext

no Fulltext

crisitem.author.dept

E163-03-2 - Forschungsgruppe Molekulare Chemie und Chemische Biologie

crisitem.author.dept

Linköping University, Sweden

crisitem.author.dept

Medical University of Graz, Austria

crisitem.author.dept

Linköping University, Sweden

crisitem.author.dept

Linköping University, Sweden

crisitem.author.dept

E163-03-2 - Forschungsgruppe Molekulare Chemie und Chemische Biologie

crisitem.author.dept

E163-03-2 - Forschungsgruppe Molekulare Chemie und Chemische Biologie

crisitem.author.dept

E163-03-2 - Forschungsgruppe Molekulare Chemie und Chemische Biologie

crisitem.author.dept

E163-03-2 - Forschungsgruppe Molekulare Chemie und Chemische Biologie

crisitem.author.dept

Linköping University, Sweden

crisitem.author.dept

Linköping University, Sweden

crisitem.author.dept

Linköping University, Sweden

crisitem.author.dept

Linköping University, Sweden

crisitem.author.dept

Linköping University, Sweden

crisitem.author.dept

Medical University of Graz, Austria

crisitem.author.dept

Medical University of Graz, Austria

crisitem.author.dept

E163-03-2 - Forschungsgruppe Molekulare Chemie und Chemische Biologie

crisitem.author.dept

E163-03-2 - Forschungsgruppe Molekulare Chemie und Chemische Biologie

crisitem.author.orcid

0000-0002-6210-4425

crisitem.author.orcid

0000-0002-6686-3568

crisitem.author.orcid

0009-0009-2470-2617

crisitem.author.orcid

0000-0001-5799-7858

crisitem.author.orcid

0009-0006-5206-469X

crisitem.author.orcid

0000-0001-6910-6813

crisitem.author.orcid

0009-0001-7662-6021

crisitem.author.orcid

0000-0002-7135-8275

crisitem.author.orcid

0000-0001-7729-0251

crisitem.author.orcid

0000-0001-5154-0291

crisitem.author.orcid

0000-0002-2799-3490

crisitem.author.orcid

0000-0001-9817-1358

crisitem.author.orcid

0000-0002-9218-9722

crisitem.author.orcid

0000-0002-6397-4254

crisitem.author.parentorg

E163-03 - Forschungsbereich Organische und Biologische Chemie

crisitem.author.parentorg

E163-03 - Forschungsbereich Organische und Biologische Chemie

crisitem.author.parentorg

E163-03 - Forschungsbereich Organische und Biologische Chemie

crisitem.author.parentorg

E163-03 - Forschungsbereich Organische und Biologische Chemie

crisitem.author.parentorg

E163-03 - Forschungsbereich Organische und Biologische Chemie

crisitem.author.parentorg

E163-03 - Forschungsbereich Organische und Biologische Chemie

crisitem.author.parentorg

E163-03 - Forschungsbereich Organische und Biologische Chemie

crisitem.project.funder

European Commission

crisitem.project.funder

European Commission

crisitem.project.funder

European Commission

crisitem.project.grantno

101099963

crisitem.project.grantno

101117736

crisitem.project.grantno

101042881

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