Baltzaki, Maria Chrysi Izampella

Fernández-Pérez, Julia

Reichsöllner, Raffael

Slezak, Paul

Redl, Heinz

Baudis, Stefan

2026-01-16T10:04:03Z

2026-01-16T10:04:03Z

2026-01

<div class="csl-bib-body"> <div class="csl-entry">Baltzaki, M. C. I., Fernández-Pérez, J., Reichsöllner, R., Slezak, P., Redl, H., &#38; Baudis, S. (2026, January). <i>From One Polymer to Many Functions: A PVA-Based Toolbox for Tissue Engineering</i> [Poster Presentation]. Alpine Winter School for Biofabrication 2026, Radstadt, Austria. http://hdl.handle.net/20.500.12708/224646</div> </div>

http://hdl.handle.net/20.500.12708/224646

Introduction Tissue regeneration needs biomaterials that combine controlled structure and function with biological relevance. Natural biomaterials offer inherent bioactivity and cell adhesion motifs, but suffer from batch variability and low tunability, limiting reproducibility. Shifting to synthetic materials offers precise control over chemistry and physical properties. FDA-approved Polyvinyl alcohol (PVA) is widely used in biomedical applications. Its functionalisation with norbornene (NB) groups allows rapid UV crosslinking into hydrogels with tunable crosslinking degree and mechanical properties. Materials & Methods Norbornene functionalised PVA (PVA-NB) was used as the hydrogel precursor and was crosslinked under UV irradiation with a dithiolated crosslinker, in presence of a photoinitiator. Hydrogels were biofunctionalised using peptides or molecules to afford different bioactive materials. These bio interactive scaffolds were studied in terms of physical properties (mechanical properties, swelling, degradation) and also cell behaviour (biocompatibility, adhesion). Alternatively, the PVA-NB hydrogel precursor was applied in an electrospinning setup to afford fibrous scaffolds. These matrices were then studied in terms of fibre morphology (diameter, porosity). Results & Discussion To demonstrate the versatility of this material platform, three modification approaches were investigated addressing biochemical and structural control. Functionalisation of PVA-NB with different bioactive motifs improved the hydrogel’s physical properties. Scaffolds reached higher storage moduli after biofunctionalisation, while stability studies showed that the hydrogels remained stable after over 1 month in physiological conditions. Also, biofunctionalisation enabled integration of bioactive cues, which is essential for tissue regeneration applications. In parallel, PVA-NB was explored in the electrospinning setup, enabling the development of ECM like structures without limiting PVA-NB’s processability. Conclusions The presented modification approaches illustrate how a single material system can be adapted across biochemical and architectural length scales. Combining biofunctionalisation and electrospinning, PVA-NB can be used as a versatile toolbox for various tissue regeneration applications.

Christian Doppler Forschungsgesells

en

Hydrogels

wound healing

From One Polymer to Many Functions: A PVA-Based Toolbox for Tissue Engineering

Presentation

Vortrag

TU Wien, Austria

Ludwig Boltzmann Gesellschaft, Austria

CDL Baudis

Poster Presentation

Christian Doppler Labor für Fortschrittliche Polymere für Biomaterialien und den 3D Druck

Cell Culture Core Facility (CCCF)

Zentrum für Kernspinresonanzspektroskopie

M2

M6

M4

Materials Characterization

Biological and Bioactive Materials

Non-metallic Materials

50

20

30

E163-02-1 - Forschungsgruppe Polymerchemie und Technologie

E308-02-3 - Forschungsgruppe 3D Printing and Biofabrication

E056-12 - Fachbereich ENROL DP

0000-0003-4121-2731

0000-0002-8375-2907

0000-0003-1654-462X

0000-0002-5390-0761

Alpine Winter School for Biofabrication 2026

Nationalstiftung für Forschung, Technologie und Entwicklung

Bundesministerium für Digitalisierung und Wirtschaftsstandort

05-01-2026

09-01-2026

On Site

Event for scientific audience

Radstadt

AT

Baltzaki, Maria Chrysi Izampella

Chemie

Chemische Verfahrenstechnik

Pharmazie, Pharmakologie, Toxikologie

1040

2040

3012

60

20

20

no Fulltext

en

Publications

none

http://purl.org/coar/resource_type/c_18co

conference poster not in proceedings

Christian Doppler Forschungsgesells

CDL Baudis

E163-02-1 - Forschungsgruppe Polymerchemie und Technologie

E308-02-3 - Forschungsgruppe 3D Printing and Biofabrication

E163-02-1 - Forschungsgruppe Polymerchemie und Technologie

TU Wien, Austria

Ludwig Boltzmann Gesellschaft, Austria

E163-02-1 - Forschungsgruppe Polymerchemie und Technologie

0000-0003-4121-2731

0000-0002-8375-2907

0000-0003-1654-462X

0000-0002-5390-0761

E163-02 - Forschungsbereich Makromolekulare Chemie

E308-02 - Forschungsbereich Polymer- und Verbundwerkstoffe

E163-02 - Forschungsbereich Makromolekulare Chemie

E163-02 - Forschungsbereich Makromolekulare Chemie