reposiTUm: Investigating the bioorthogonality of isocyanides

DC Field

Value

Language

dc.contributor.author

Nakao, Ryota

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dc.contributor.author

Savic, Viktor

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dc.contributor.author

Miles, Jennifer A

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dc.contributor.author

Livingstone, Keith

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dc.contributor.author

Mihovilovic, Marko D.

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dc.contributor.author

Raubo, Piotr

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dc.contributor.author

Warriner, Stuart L

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dc.contributor.author

Wright, Megan H

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dc.date.accessioned

2026-01-16T13:39:05Z

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dc.date.available

2026-01-16T13:39:05Z

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dc.date.issued

2026

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dc.identifier.citation

<div class="csl-bib-body"> <div class="csl-entry">Nakao, R., Savic, V., Miles, J. A., Livingstone, K., Mihovilovic, M. D., Raubo, P., Warriner, S. L., & Wright, M. H. (2026). Investigating the bioorthogonality of isocyanides. <i>Chemical Communications</i>. https://doi.org/10.1039/d5cc04136h</div> </div>

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dc.identifier.issn

1359-7345

-

dc.identifier.uri

http://hdl.handle.net/20.500.12708/224669

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dc.description.abstract

Isocyanides have been applied in bioorthogonal reactions as triggers for uncaging reactions. However, emerging evidence suggests that they may label proteins covalently. We synthesised a fluorophore-conjugated isocyanide and analysed its protein reactivity. Our results suggest that isocyanides cannot be considered to be bioorthogonal in chemical biology.

en

dc.description.sponsorship

FWF - Österr. Wissenschaftsfonds

-

dc.language.iso

en

-

dc.publisher

ROYAL SOC CHEMISTRY

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dc.relation.ispartof

Chemical Communications

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dc.subject

Bioorthogonal Chemistry

en

dc.subject

Isocyanides

en

dc.title

Investigating the bioorthogonality of isocyanides

en

dc.type

Article

en

dc.type

Artikel

de

dc.identifier.pmid

41439795

-

dc.identifier.scopus

2-s2.0-105025572366

-

dc.identifier.url

https://api.elsevier.com/content/abstract/scopus_id/105025572366

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dc.contributor.affiliation

University of Leeds, United Kingdom of Great Britain and Northern Ireland (the)

-

dc.contributor.affiliation

University of Leeds, United Kingdom of Great Britain and Northern Ireland (the)

-

dc.contributor.affiliation

University of Leeds, United Kingdom of Great Britain and Northern Ireland (the)

-

dc.contributor.affiliation

AstraZeneca (United Kingdom), United Kingdom of Great Britain and Northern Ireland (the)

-

dc.contributor.affiliation

University of Leeds, United Kingdom of Great Britain and Northern Ireland (the)

-

dc.contributor.affiliation

University of Leeds, United Kingdom of Great Britain and Northern Ireland (the)

-

dc.relation.grantno

DK W1232-B11

-

dc.type.category

Original Research Article

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tuw.journal.peerreviewed

true

-

tuw.peerreviewed

true

-

wb.publication.intCoWork

International Co-publication

-

tuw.project.title

Doktoratskolleg W 1232-B11

-

tuw.researchTopic.id

X1

-

tuw.researchTopic.name

Beyond TUW-research focus

-

tuw.researchTopic.value

100

-

dcterms.isPartOf.title

Chemical Communications

-

tuw.publication.orgunit

E163-03-4 - Forschungsgruppe Bioorganische Synthesechemie

-

tuw.publication.orgunit

E056-12 - Fachbereich ENROL DP

-

tuw.publication.orgunit

E056-24 - Fachbereich GreenChem-TechHub

-

tuw.publisher.doi

10.1039/d5cc04136h

-

dc.date.onlinefirst

2025-12-15

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dc.identifier.eissn

1364-548X

-

dc.description.numberOfPages

5

-

tuw.author.orcid

0000-0001-5357-6597

-

tuw.author.orcid

0000-0001-8839-9201

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tuw.author.orcid

0000-0002-4169-3056

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tuw.author.orcid

0000-0002-5438-8368

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tuw.author.orcid

0000-0002-2365-0976

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tuw.author.orcid

0000-0002-7589-6011

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tuw.author.orcid

0000-0003-2731-4707

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wb.sci

true

-

wb.sciencebranch

Chemie

-

wb.sciencebranch

Chemische Verfahrenstechnik

-

wb.sciencebranch

Pharmazie, Pharmakologie, Toxikologie

-

wb.sciencebranch.oefos

1040

-

wb.sciencebranch.oefos

2040

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wb.sciencebranch.oefos

3012

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wb.sciencebranch.value

60

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wb.sciencebranch.value

20

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wb.sciencebranch.value

20

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item.cerifentitytype

Publications

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item.languageiso639-1

en

-

item.fulltext

no Fulltext

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item.openairetype

research article

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item.grantfulltext

none

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item.openairecristype

http://purl.org/coar/resource_type/c_2df8fbb1

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crisitem.author.dept

University of Leeds

-

crisitem.author.dept

E163-03-4 - Forschungsgruppe Bioorganische Synthesechemie

-

crisitem.author.dept

University of Leeds

-

crisitem.author.dept

University of Leeds

-

crisitem.author.dept

E163-03-4 - Forschungsgruppe Bioorganische Synthesechemie

-

crisitem.author.dept

AstraZeneca (United Kingdom)

-

crisitem.author.dept

University of Leeds

-

crisitem.author.dept

University of Leeds

-

crisitem.author.orcid

0000-0001-5357-6597

-

crisitem.author.orcid

0000-0001-8839-9201

-

crisitem.author.orcid

0000-0002-4169-3056

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crisitem.author.orcid

0000-0002-5438-8368

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crisitem.author.orcid

0000-0002-2365-0976

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crisitem.author.orcid

0000-0002-7589-6011

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crisitem.author.orcid

0000-0003-2731-4707

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crisitem.author.parentorg

E163-03 - Forschungsbereich Organische und Biologische Chemie

-

crisitem.author.parentorg

E163-03 - Forschungsbereich Organische und Biologische Chemie

-

crisitem.project.funder

FWF - Österr. Wissenschaftsfonds

-

crisitem.project.grantno

DK W1232-B11

-

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