<div class="csl-bib-body">
<div class="csl-entry">Groß, F. S., Oleinik, E., Andreas Teuschl, & Thurner, P. (2025, September 30). <i>From Displacement to Stress Control: Evaluating Bioreactor Mechanical Stimulation</i> [Poster Presentation]. 10th Biennial European Cell Mechanics Meeting, Leuven, Belgium. http://hdl.handle.net/20.500.12708/224797</div>
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dc.identifier.uri
http://hdl.handle.net/20.500.12708/224797
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dc.description.abstract
In tissue engineering, mechanical stimulation is used to guide cellular adaptation and tissue development. While a number of bioreactors can apply displacement-controlled strain on scaffolds, emerging evidence suggests that cells respond more to stress rather than strain. In this study, we assess the limitations of displacement-controlled stimulation and investigate an approach of stress control in bioreactors.
In our application, the MagneTissue bioreactor applies strain to fibrin rings, which serve as cell scaffolds for tendon tissue modeling. Due to the displacement-controlled nature of the system, the resulting forces and stresses after applying strain remain unknown. It is also unknown, how stresses evolve over time and how relaxation of the scaffold affects the mechanical stimulus on cells. To address these limitations, one of the bioreactor’s loading protocols was replicated on a universal testing setup in a PBS bath, measuring the mechanical response of fibrin rings without cells. The results show that stiffness, expressed as the experienced stress after applying a strain of 20 %, varies for fibrin rings. Additionally, stress relaxation, stress recovery and plastic deformation of the fibrin constructs are observed.
A model consisting of Maxwell bodies in parallel is used to describe the mechanical behavior of the ring constructs. This model can be used to predict stresses experienced in the bioreactor. Hence, strain protocols can be adjusted to control stresses within the scaffold and counteract its viscoelastic behavior. This approach aims to enhance bioreactor precision and optimize mechanical stimulation protocols for better control of cell growth.
en
dc.language.iso
en
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dc.subject
Tissue Engineering
en
dc.title
From Displacement to Stress Control: Evaluating Bioreactor Mechanical Stimulation
en
dc.type
Presentation
en
dc.type
Vortrag
de
dc.contributor.affiliation
University of Applied Sciences Technikum Wien
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dc.type.category
Poster Presentation
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tuw.researchTopic.id
M2
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tuw.researchTopic.id
M6
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tuw.researchTopic.name
Materials Characterization
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tuw.researchTopic.name
Biological and Bioactive Materials
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tuw.researchTopic.value
20
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tuw.researchTopic.value
80
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tuw.publication.orgunit
E317-02 - Forschungsbereich Biomechanik
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tuw.publication.orgunit
E056-14 - Fachbereich Mature Tissue
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tuw.publication.orgunit
E317-02 - Forschungsbereich Biomechanik
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tuw.publication.orgunit
E056-14 - Fachbereich Mature Tissue
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tuw.publication.orgunit
E902-02 - Fachbereich Vorsitzende der Studienkommissionen
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tuw.author.orcid
0000-0002-3817-1572
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tuw.author.orcid
0000-0001-7588-9041
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tuw.event.name
10th Biennial European Cell Mechanics Meeting
en
tuw.event.startdate
30-09-2025
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tuw.event.enddate
03-10-2025
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tuw.event.online
On Site
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tuw.event.type
Event for scientific audience
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tuw.event.place
Leuven
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tuw.event.country
BE
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tuw.event.institution
KU Leuven
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tuw.event.presenter
Groß, Felix Sebastian
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tuw.event.track
Single Track
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wb.sciencebranch
Maschinenbau
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wb.sciencebranch
Sonstige Technische Wissenschaften
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wb.sciencebranch
Sonstige Humanmedizin, Gesundheitswissenschaften
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wb.sciencebranch.oefos
2030
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wb.sciencebranch.oefos
2119
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wb.sciencebranch.oefos
3059
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wb.sciencebranch.value
40
-
wb.sciencebranch.value
30
-
wb.sciencebranch.value
30
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item.openairetype
conference poster not in proceedings
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item.openairecristype
http://purl.org/coar/resource_type/c_18co
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item.cerifentitytype
Publications
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item.languageiso639-1
en
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item.grantfulltext
none
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item.fulltext
no Fulltext
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crisitem.author.dept
E317-02 - Forschungsbereich Biomechanik
-
crisitem.author.dept
E317-02 - Forschungsbereich Biomechanik
-
crisitem.author.dept
University of Applied Sciences Technikum Wien
-
crisitem.author.dept
E317 - Institut für Leichtbau und Struktur-Biomechanik
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crisitem.author.orcid
0009-0002-6690-5999
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crisitem.author.orcid
0000-0002-3817-1572
-
crisitem.author.orcid
0000-0001-7588-9041
-
crisitem.author.parentorg
E317 - Institut für Leichtbau und Struktur-Biomechanik
-
crisitem.author.parentorg
E317 - Institut für Leichtbau und Struktur-Biomechanik
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crisitem.author.parentorg
E300 - Fakultät für Maschinenwesen und Betriebswissenschaften
