Stöcker, Yvonne Madeleine

Augustin, Christoph

Gonzalo, Alejandro

Telle, Åshild

Guerrero Hurtado, Manuel

Flores, Oscar

Plank, Gernot

Akoum, Nazem

Boyle, Patrick M

del Álamo, Juan Carlos

García-Villalba, Manuel

2026-02-05T11:03:18Z

2026-02-05T11:03:18Z

2025-09-22

<div class="csl-bib-body"> <div class="csl-entry">Stöcker, Y. M., Augustin, C., Gonzalo, A., Telle, Å., Guerrero Hurtado, M., Flores, O., Plank, G., Akoum, N., Boyle, P. M., del Álamo, J. C., &#38; García-Villalba, M. (2025, September 22). <i>Effect of fibrosis on flow in the left atrium</i> [Conference Presentation]. 11th GACM Colloquium on Computational Mechanics for Young Scientists from Academia and Industry, Braunschweig, Germany.</div> </div>

http://hdl.handle.net/20.500.12708/225927

The left atrial appendage (LAA) is a small pouch located in the left atrium (LA). It is the most common thrombosis site due to its tendency to accumulate stagnant blood, especially when endocardial motion is impaired (e.g., due to fibrotic tissue or atrial fibrillation). The resulting blood stasis leads to an increased risk of blood clot formation and ischemic stroke. Although the underlying mechanisms of coagulation and thrombogenesis are complex, the residence time (RT) of blood inside the cavity is often used as a surrogate marker for stasis and a risk index for thrombosis. Previous studies employed computational fluid dynamics (CFD) analysis to investigate how deranged atrial wall motion impacts flow and LAA stasis. However, most of these works used simplified models for atrial wall motion. There is thus a paucity of mechanistic studies resolving the effect of tissue fibrosis. To bridge this gap, we perform high-resolution, patient-specific electro-mechanical (EM) simulations of the cardiac tissue. The EM model gives us the possibility to apply several different fibrosis patterns to the same underlying LA anatomy. In addition to the fibrosis pattern, we can separately vary the amount of fibrotic tissue (i.e., fibrosis burden). Based on the resulting set of distinct motion profiles for the same baseline LA geometry, we perform CFD simulations. This allows us to independently investigate the effects of fibrosis burden and pattern on the CFD results, in particular, the LA and LAA blood RTs. The results suggest that the changes of RT inside the LA are mainly determined by the amount of fibrosis and only marginally sensitive to the specific pattern. In contrast, the RT inside the LAA is influenced by non-trivial changes in the global flow dynamics and is sensitive to both fibrosis pattern and burden.

en

CFD

left atrium

fibrosis

Effect of fibrosis on flow in the left atrium

Presentation

Vortrag

Medical University of Graz, Austria

University of Washington, United States of America (the)

University of Washington, United States of America (the)

Universidad Carlos III de Madrid, Spain

Universidad Carlos III de Madrid, Spain

Medical University of Graz, Austria

University of Washington, United States of America (the)

University of Washington, United States of America (the)

University of Washington, United States of America (the)

Conference Presentation

Vienna Scientific Cluster

C2

C6

C1

Computational Fluid Dynamics

Modeling and Simulation

Computational Materials Science

60

20

20

E322-02 - Forschungsbereich Numerische Strömungsmechanik

0009-0001-2531-0326

0000-0001-6341-4014

0000-0001-7492-5741

0000-0001-5399-4094

0009-0004-7664-8484

0000-0003-2365-0738

0000-0002-7380-6908

0000-0002-2001-6806

0000-0001-9048-1239

0000-0001-5683-0239

0000-0002-6953-2270

11th GACM Colloquium on Computational Mechanics for Young Scientists from Academia and Industry

21-09-2025

24-09-2025

On Site

Event for scientific audience

Braunschweig

DE

Stöcker, Yvonne Madeleine

Medizintechnik

Maschinenbau

Physik, Astronomie

2060

2030

1030

25

25

50

http://purl.org/coar/resource_type/c_18cp

no Fulltext

en

none

conference paper not in proceedings

Publications

E322-02 - Forschungsbereich Numerische Strömungsmechanik

Medical University of Graz, Austria

University of Washington, United States of America (the)

University of Washington, United States of America (the)

Universidad Carlos III de Madrid, Spain

Universidad Carlos III de Madrid, Spain

Medical University of Graz, Austria

University of Washington, United States of America (the)

University of Washington, United States of America (the)

University of Washington, United States of America (the)

E322-02 - Forschungsbereich Numerische Strömungsmechanik

0009-0001-2531-0326

0000-0001-6341-4014

0000-0001-7492-5741

0000-0001-5399-4094

0009-0004-7664-8484

0000-0003-2365-0738

0000-0002-7380-6908

0000-0002-2001-6806

0000-0001-9048-1239

0000-0001-5683-0239

0000-0002-6953-2270

E322 - Institut für Strömungsmechanik und Wärmeübertragung

E322 - Institut für Strömungsmechanik und Wärmeübertragung