<div class="csl-bib-body">
<div class="csl-entry">Barutel, C. M. A., & Fürthauer, S. (2026, March 13). <i>Theory of Forces Between Crosslinked Filaments</i> [Presentation]. DPG Spring Meeting 2026 of the Condensed Matter Section (SKM), Dresden, Germany.</div>
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The cytoskeleton drives essential cellular processes like cell division and chromosome segregation. It consists of filaments that are crosslinked by proteins, many of which are molecular scale motors that consume ATP to do work. The forces that crosslinking proteins generate between cytoskeletal filaments are the key drivers of active cellular mechanics. We derive a generic theory to describe such crosslinking forces.
We construct a theory to describe and predict the forces generated collectively by crosslinking proteins between biofilaments using symmetries, conservation laws, and out-of equilibrium thermodynamic principles. Our approach identifies the full set of phenomenological coefficients governing entropic, active, and frictional crosslinking forces, which allows a quantitative comparison between the effects of different crosslinker mixtures between two filaments. We demonstrate the power and validity of this framework by quantitatively explaining a set of different experimental setups, which combine the effects of passive and active crosslinks
en
dc.language.iso
en
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dc.subject
Thermodynamics
en
dc.subject
Molecular Motors
en
dc.subject
Cytoskeleton
en
dc.subject
Active matter
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dc.subject
Filament interaction
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dc.title
Theory of Forces Between Crosslinked Filaments
en
dc.type
Presentation
en
dc.type
Vortrag
de
dc.type.category
Presentation
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tuw.researchTopic.id
M6
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tuw.researchTopic.name
Biological and Bioactive Materials
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tuw.researchTopic.value
100
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tuw.publication.orgunit
E134-04 - Forschungsbereich Biophysics
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tuw.author.orcid
0000-0001-9581-5963
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tuw.event.name
DPG Spring Meeting 2026 of the Condensed Matter Section (SKM)
