<div class="csl-bib-body">
<div class="csl-entry">Templ, J., Schnürch, M., & Borchardt, L. (2026, June 23). <i>Mechanochemical Strategies for the Late-Stage Functionalization of Bioactive Compounds</i> [Conference Presentation]. 21st Blue Danube Symposium on Heterocycles in Chemistry (21st BDSHC), Györ, Hungary.</div>
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dc.identifier.uri
http://hdl.handle.net/20.500.12708/229586
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dc.description.abstract
Mechanochemistry has emerged as a transformative approach in synthetic chemistry, utilizing
mechanical energy to drive chemical transformations. Its capacity to operate under solvent-free conditions reduces solvent waste, simplifies purification, and lowers the environmental footprint of chemical processes. With growing environmental awareness, mechanochemical methods are expected to become increasingly important for both synthesis and the late-stage functionalization (LSF) of active pharmaceutical ingredients (APIs).
Several mechanochemical strategies for the functionalization of heterocyclic compounds, with
a focus on the LSF of bioactive molecules, are presented. These include a solvent-free Tsuji–
Trost allylation, an ultra-fast Wittig olefination and a direct mechanocatalytic Heck reaction. The methods are compared with established solution-based protocols, highlighting mechanochemistry’s potential for pharmaceutical synthesis.
In addition, kinetic studies of solvent-free mechanochemical reactions are discussed, showing that ball-milling processes are impact-driven rather than mixing-controlled and scale linearly with single-impact energy.
en
dc.description.sponsorship
FWF - Österr. Wissenschaftsfonds
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dc.language.iso
en
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dc.subject
Mechanochemistry
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dc.subject
sustainable synthesis
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dc.subject
Ball Milling
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dc.subject
Green API Synthesis
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dc.subject
kinetic studies
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dc.title
Mechanochemical Strategies for the Late-Stage Functionalization of Bioactive Compounds
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dc.type
Presentation
en
dc.type
Vortrag
de
dc.contributor.affiliation
Ruhr University Bochum, Germany
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dc.relation.grantno
J 4922
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dc.type.category
Conference Presentation
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tuw.project.title
Entwicklung von i-BM in der Direkten Kupfer Mechanokatalyse
