<div class="csl-bib-body">
<div class="csl-entry">Lebedeva, A., Andriotis, O., Tögel, S., Marchetti-Deschmann, M., & Thurner, P. (2026, September 22). <i>Microscale Mapping of Human Meniscus Biomechanics and Biochemistry by AFM Micro-indentation and MALDI-FTICR Mass Spectrometry Imaging</i> [Conference Presentation]. Chemietage 2026, Krems, Austria. http://hdl.handle.net/20.500.12708/231248</div>
</div>
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dc.identifier.uri
http://hdl.handle.net/20.500.12708/231248
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dc.description.abstract
The multimodal approach combining AFM micro-indentation and MALDI-FTICR mass spectrometry imaging was applied to investigate the local biomechanical and biochemical properties of healthy and osteoarthritic human menisci. Healthy menisci exhibited a distinct zonal stiffness gradient and coherent spatial organization of extracellular-matrix components. Osteoarthritic tissues showed reduced mechanical heterogeneity, disrupted molecular gradients, and localized ECM remodelling. Spatial integration of both datasets revealed associations between mechanical softening and altered matrix composition, providing new insight into meniscal structure–property relationships and their disruption during osteoarthritis.
en
dc.language.iso
en
-
dc.subject
human meniscus
en
dc.subject
Osteoarthritis
en
dc.subject
AFM micro-indentation
en
dc.subject
MALDI-FTICR MSI
en
dc.subject
Extracellular Matrix
en
dc.title
Microscale Mapping of Human Meniscus Biomechanics and Biochemistry by AFM Micro-indentation and MALDI-FTICR Mass Spectrometry Imaging
en
dc.type
Presentation
en
dc.type
Vortrag
de
dc.contributor.affiliation
Medical University of Vienna, Austria
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dc.type.category
Conference Presentation
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tuw.researchTopic.id
M2
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tuw.researchTopic.id
M6
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tuw.researchTopic.name
Materials Characterization
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tuw.researchTopic.name
Biological and Bioactive Materials
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tuw.researchTopic.value
50
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tuw.researchTopic.value
50
-
tuw.publication.orgunit
E164-01-1 - Forschungsgruppe Massenspektrometrische Bio- und Polymeranalytik
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tuw.publication.orgunit
E317-02 - Forschungsbereich Biomechanik
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tuw.publication.orgunit
E056-12 - Fachbereich ENROL DP
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tuw.publication.orgunit
E056-04 - Fachbereich TU-DX: Towards Applications of 2D Materials
-
tuw.publication.orgunit
E056-14 - Fachbereich Mature Tissue
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tuw.author.orcid
0000-0003-4107-1510
-
tuw.author.orcid
0000-0002-8060-7851
-
tuw.author.orcid
0000-0001-7588-9041
-
tuw.event.name
Chemietage 2026
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tuw.event.startdate
21-09-2026
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tuw.event.enddate
23-09-2026
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tuw.event.online
On Site
-
tuw.event.type
Event for scientific audience
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tuw.event.place
Krems
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tuw.event.country
AT
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tuw.event.institution
Österreichische Chemische Gesellschaft
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tuw.event.presenter
Lebedeva, Aleksandra
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tuw.event.track
Multi Track
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wb.sciencebranch
Chemie
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wb.sciencebranch.oefos
1040
-
wb.sciencebranch.value
100
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item.openairetype
conference paper not in proceedings
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item.openairecristype
http://purl.org/coar/resource_type/c_18cp
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item.languageiso639-1
en
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item.fulltext
no Fulltext
-
item.cerifentitytype
Publications
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item.grantfulltext
none
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crisitem.author.dept
E317-02 - Forschungsbereich Biomechanik
-
crisitem.author.dept
E317-02 - Forschungsbereich Biomechanik
-
crisitem.author.dept
Medical University of Vienna, Austria
-
crisitem.author.dept
E164-01-1 - Forschungsgruppe Massenspektrometrische Bio- und Polymeranalytik
-
crisitem.author.dept
E317 - Institut für Leichtbau und Struktur-Biomechanik
-
crisitem.author.orcid
0000-0003-4107-1510
-
crisitem.author.orcid
0000-0002-8060-7851
-
crisitem.author.orcid
0000-0001-7588-9041
-
crisitem.author.parentorg
E317 - Institut für Leichtbau und Struktur-Biomechanik
-
crisitem.author.parentorg
E317 - Institut für Leichtbau und Struktur-Biomechanik
-
crisitem.author.parentorg
E164-01 - Forschungsbereich Imaging und Instrumentelle Analytische Chemie
-
crisitem.author.parentorg
E300 - Fakultät für Maschinenwesen und Betriebswissenschaften
