<div class="csl-bib-body">
<div class="csl-entry">Lebedeva, A., Andriotis, O., Marchetti-Deschmann, M., & Thurner, P. (2026, August 26). <i>High-Resolution MALDI-FTICR IMS Reveals Compartment-Specific Molecular Signatures Linked to Tendon Mechanics and Ageing</i> [Conference Presentation]. IMSC 2026, Lyon, France. http://hdl.handle.net/20.500.12708/231253</div>
</div>
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dc.identifier.uri
http://hdl.handle.net/20.500.12708/231253
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dc.description.abstract
This study integrated AFM micro-indentation with MALDI-FTICR mass spectrometry imaging to spatially correlate the mechanical and molecular properties of healthy and osteoarthritic human menisci. Healthy menisci exhibited a distinct zonal stiffness gradient and coherent molecular organization, whereas osteoarthritic tissues showed reduced zonal mechanical differences, disrupted molecular gradients, and localized matrix remodelling. The correlative workflow revealed spatial associations between mechanical softening and altered ECM organization, providing a platform for characterizing meniscal degeneration at the microscale.
en
dc.language.iso
en
-
dc.subject
Tendon
en
dc.subject
fascicular and interfascicular matrices
en
dc.subject
MALDI-FTICR MSI
en
dc.subject
AFM micro-indentation
en
dc.subject
Ageing
en
dc.title
High-Resolution MALDI-FTICR IMS Reveals Compartment-Specific Molecular Signatures Linked to Tendon Mechanics and Ageing
en
dc.type
Presentation
en
dc.type
Vortrag
de
dc.contributor.affiliation
Institut für Leichtbau und Struktur-Biomechanik, Wien, Austria
-
dc.contributor.affiliation
Institut für Leichtbau und Struktur-Biomechanik, Wien, Austria
-
dc.contributor.affiliation
Institut für Leichtbau und Struktur-Biomechanik, Wien, Austria
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dc.type.category
Conference Presentation
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tuw.researchTopic.id
M2
-
tuw.researchTopic.id
M6
-
tuw.researchTopic.name
Materials Characterization
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tuw.researchTopic.name
Biological and Bioactive Materials
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tuw.researchTopic.value
50
-
tuw.researchTopic.value
50
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tuw.publication.orgunit
E056-12 - Fachbereich ENROL DP
-
tuw.publication.orgunit
E164-01-1 - Forschungsgruppe Massenspektrometrische Bio- und Polymeranalytik
-
tuw.publication.orgunit
E056-04 - Fachbereich TU-DX: Towards Applications of 2D Materials
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tuw.publication.orgunit
E056-14 - Fachbereich Mature Tissue
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tuw.author.orcid
0000-0003-4107-1510
-
tuw.author.orcid
0000-0002-8060-7851
-
tuw.author.orcid
0000-0001-7588-9041
-
tuw.event.name
IMSC 2026
en
tuw.event.startdate
22-08-2026
-
tuw.event.enddate
27-08-2026
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tuw.event.online
On Site
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tuw.event.type
Event for scientific audience
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tuw.event.place
Lyon
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tuw.event.country
FR
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tuw.event.presenter
Lebedeva, Aleksandra
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wb.sciencebranch
Chemie
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wb.sciencebranch.oefos
1040
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wb.sciencebranch.value
100
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item.openairetype
conference paper not in proceedings
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item.openairecristype
http://purl.org/coar/resource_type/c_18cp
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item.languageiso639-1
en
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item.fulltext
no Fulltext
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item.cerifentitytype
Publications
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item.grantfulltext
none
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crisitem.author.dept
E317-02 - Forschungsbereich Biomechanik
-
crisitem.author.dept
E317-02 - Forschungsbereich Biomechanik
-
crisitem.author.dept
E164-01-1 - Forschungsgruppe Massenspektrometrische Bio- und Polymeranalytik
-
crisitem.author.dept
E317 - Institut für Leichtbau und Struktur-Biomechanik
-
crisitem.author.orcid
0000-0003-4107-1510
-
crisitem.author.orcid
0000-0002-8060-7851
-
crisitem.author.orcid
0000-0001-7588-9041
-
crisitem.author.parentorg
E317 - Institut für Leichtbau und Struktur-Biomechanik
-
crisitem.author.parentorg
E317 - Institut für Leichtbau und Struktur-Biomechanik
-
crisitem.author.parentorg
E164-01 - Forschungsbereich Imaging und Instrumentelle Analytische Chemie
-
crisitem.author.parentorg
E300 - Fakultät für Maschinenwesen und Betriebswissenschaften
