<div class="csl-bib-body">
<div class="csl-entry">Schwaighofer, A., Brandstetter, M., & Lendl, B. (2017). Quantum cascade lasers (QCLs) in biomedical spectroscopy. <i>Chemical Society Reviews</i>. https://doi.org/10.1039/C7CS00403F</div>
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Quantum cascade lasers (QCL) are the first room temperature semiconductor laser source for the mid-IR spectral region, triggering substantial development for the advancement of mid-IR spectroscopy. Mid-IR spectroscopy in general provides rapid, label-free and objective analysis, particularly important in the field of biomedical analysis. Due to their unique properties, QCLs offer new possibilities for development of analytical methods to enable quantification of clinically relevant concentration levels and to support medical diagnostics. Compared to FTIR spectroscopy, novel and elaborated measurement techniques can be implemented that allow miniaturized and portable instrumentation. This review illustrates the characteristics of QCLs with a particular focus on their benefits for biomedical analysis. Recent applications of QCL-based spectroscopy for analysis of a variety of clinically relevant samples including breath, urine, blood, interstitial fluid, and biopsy samples are summarized. Further potential for technical advancements is discussed in combination with future prospects for employment of QCL-based devices in routine and point-of-care diagnostics.
en
dc.description.sponsorship
Austrian research funding association (FFG)
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dc.language
English
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dc.language.iso
en
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dc.publisher
Royal Society of Chemistry
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dc.relation.ispartof
Chemical Society Reviews
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dc.subject
Quantum cascade lasers
en
dc.title
Quantum cascade lasers (QCLs) in biomedical spectroscopy
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dc.type
Article
en
dc.type
Artikel
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843546
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Review Article
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Chemical Society Reviews
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E164 - Institut für Chemische Technologien und Analytik
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tuw.publisher.doi
10.1039/C7CS00403F
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dc.date.onlinefirst
2017-08-17
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dc.identifier.eissn
1460-4744
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AC15516513
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urn:nbn:at:at-ubtuw:3-7430
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0000-0003-2714-7056
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0000-0003-3838-5842
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en
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Open Access
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review article
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open
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E164-02-1 - Forschungsgruppe Prozessanalytik
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E164 - Institut für Chemische Technologien und Analytik
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crisitem.author.dept
E164-02 - Forschungsbereich Umwelt-, Prozessanalytik und Sensoren
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0000-0003-2714-7056
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0000-0003-3838-5842
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E164-02 - Forschungsbereich Umwelt-, Prozessanalytik und Sensoren
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E150 - Fakultät für Technische Chemie
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E164 - Institut für Chemische Technologien und Analytik