dc.description.abstract
Gadolinium-based contrast media are routinely used in magnetic resonance imaging (MRI).
Until recently gadolinium-based contrast media were considered to be rather safe in
diagnostical applications, though in patients with kidney disease it could cause nephrogenic
systemic fibrosis [1]. However, some studies revealed that gadolinium (Gd) is not cleared
from the body completely and that some tissues and organs retain gadolinium for a very long
time [2,3]. Free gadolinium is extremely toxic for the human organism, and, if released from
depot, might pose a serious health threat.
The recent findings showed that the contrast agent is not fully excreted, and the accumulation
of gadolinium in brain tissue even in subjects without renal dysfunction was observed [3,4].
The other possible depots of gadolinium are bone and cartilage tissue.
To prove this assumption, various samples of bone tissue from patients, who previously
received MRI, were analyzed using 2 D imaging with 20μm and higher resolution (< 1 μm).
Our aim was to investigate the distribution of gadolinium in human bone, and the obtained
results will be demonstrated. To the best of our knowledge these measurements are the first
attempt of imaging Gd accumulations in the bone tissue, which is of exceptional interest for
understanding the mechanisms of such accumulations and, further, for predictions of safety of
Gd-based contrast media in different bone diseases and associated conditions [5].
[1] Grobner, T. Nephrol. Dial. Transplant. 21, 2006, 1745–1745.
[2] Darrah, T. H.; Prutsman-Pfeiffer, J. J.; Poreda, R. J.; Ellen Campbell, M.; Hauschka, P. V; Hannigan, R.
E. Metallomics 1, 2009, 479–88.
[3] Kanda, T.; Fukusato, T.; Matsuda, M.; Toyoda, K.; Oba, H.; Kotoku, J.; Haruyama, T.; Kitajima, K.;
Furui, S. Radiology 276, 2015, 228–32.
[4] McDonald, R. J.; McDonald, J. S.; Kallmes, D. F.; Jentoft, M. E.; Murray, D. L.; Thielen, K. R.;
Williamson, E. E.; Eckel, L. J. Radiology 275, 2015, 772–782.
[5] Turyanskaya, A.; Rauwolf, M.; Pichler, V.; Simon, R.; Burghammer, M.; Fox, O. J.L.; Sawhney, K.;
Hofstaetter, J. G.; Roschger, A.; Roschger, P.; Wobrauschek, P.; Streli, C. Sci Rep 10, 2020, 6301.
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