<div class="csl-bib-body">
<div class="csl-entry">Bassereh Moosaabadi, H. (2019). <i>Simulation of the synaptic exocytosis of bipolar cells in the electrically stimulated mammalian retina</i> [Dissertation, Technische Universität Wien]. reposiTUm. https://doi.org/10.34726/hss.2019.47065</div>
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dc.identifier.uri
https://doi.org/10.34726/hss.2019.47065
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dc.identifier.uri
http://hdl.handle.net/20.500.12708/8560
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dc.description
Abweichender Titel nach Übersetzung der Verfasserin/des Verfassers
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dc.description.abstract
The output of the retinal bipolar neurons has two components, i.e., transient and sustained neurotransmitter releases, which is not common at chemical synapses. This uniqueness originates from an extra protein structure called 'ribbon'. Transient outputs take place exactly after a large enough stimulus, while sustained outputs occur at any state with a different rate. We presented two models to simulate both releases from a terminal of a rat rod bipolar cell, but the approach can be applied for any type of bipolar cells. One of the models is based on transmembrane voltage of terminals and the other is based on intracellular calcium concentration of terminals, each of which is explained by two time dependent equations. Intracellular calcium concentration method bring a 0.43 ms signal delay observable in xperiments, while the other model has no delay. By comparing responses of spiking and non-spiking bipolar cells stimulated intracellularly, it was proposed that a spike causes the release of all of the available vesicles rapidly (transient releases), while the non-spiking cell release no vesicle at the same stimulus amplitude. Effect of extracellular stimulation generated by a single microelectrode, on transient release almost suggested no difference between responses of active and passive cells in short pulses because terminal membrane of the cells in both cases senses the same potentials originating from the microelectrode. However, spiking-bipolar cells release more transient vesicles in pulses with long duration since spike has enough time to reach to the terminal leading to release of more transient vesicles. Effect of periodic stimulation on ribbon recovery when the cell is stimulated both intraor extracellularly also suggested that for 5 Hz stimulations, only three transient vesicles are released from a single ribbon per stimulus.
en
dc.language
English
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dc.language.iso
en
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dc.rights.uri
http://rightsstatements.org/vocab/InC/1.0/
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dc.subject
ribbon synapse
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dc.subject
retina
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dc.subject
bipolar cell
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dc.subject
stimulation
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dc.subject
simulation
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dc.title
Simulation of the synaptic exocytosis of bipolar cells in the electrically stimulated mammalian retina
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dc.title.alternative
Simulation der Neurotransmitterausschüttung von Bipolarzellen der elektrisch stimulierten Retina
de
dc.type
Thesis
en
dc.type
Hochschulschrift
de
dc.rights.license
In Copyright
en
dc.rights.license
Urheberrechtsschutz
de
dc.identifier.doi
10.34726/hss.2019.47065
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dc.contributor.affiliation
TU Wien, Österreich
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dc.rights.holder
Hassan Bassereh Moosaabadi
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dc.publisher.place
Wien
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tuw.version
vor
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tuw.thesisinformation
Technische Universität Wien
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tuw.publication.orgunit
E101 - Institut für Analysis und Scientific Computing
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dc.type.qualificationlevel
Doctoral
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dc.identifier.libraryid
AC15391421
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dc.description.numberOfPages
148
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dc.identifier.urn
urn:nbn:at:at-ubtuw:1-126035
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dc.thesistype
Dissertation
de
dc.thesistype
Dissertation
en
dc.rights.identifier
In Copyright
en
dc.rights.identifier
Urheberrechtsschutz
de
tuw.advisor.staffStatus
staff
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item.openaccessfulltext
Open Access
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item.openairecristype
http://purl.org/coar/resource_type/c_db06
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item.grantfulltext
open
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item.mimetype
application/pdf
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item.languageiso639-1
en
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item.openairetype
doctoral thesis
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item.fulltext
with Fulltext
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item.cerifentitytype
Publications
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crisitem.author.dept
E101-03 - Forschungsbereich Scientific Computing and Modelling
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crisitem.author.parentorg
E101 - Institut für Analysis und Scientific Computing