<div class="csl-bib-body">
<div class="csl-entry">Lunzer, M., Maryasin, B., Zandrini, T., Baudis, S., Ovsianikov, A., & Liska, R. (2022). A disulfide-based linker for thiol-norbornene conjugation: formation and cleavage of hydrogels by the use of light. <i>Polymer Chemistry</i>, <i>13</i>(9), 1158–1168. https://doi.org/10.1039/d1py00914a</div>
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dc.identifier.issn
1759-9954
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dc.identifier.uri
http://hdl.handle.net/20.500.12708/87323
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dc.description.abstract
Photolabile groups are the key components of photo-responsive polymers, dynamically tunable materials with multiple applications in materials and life sciences. They usually consist of a chromophore and a labile bond and are inherently light sensitive. An exception are disulfides, simple reversible linkages, which become photocleavable upon addition of a photoinitiator. Despite their practical features, disulfides are rarely utilized due to their impractical formation. Here, we report a disulfide-based linker series bearing norbornene terminals for facile crosslinking of thiol-functionalized macromers via light-triggered thiol-ene conjugation (TEC). Besides finding a highly reactive lead compound, we also identify an unexpected TEC-retardation, strongly dependent on the molecular linker structure and affecting hydrogel stability. Finally, we present a useful method for localized disulfide cleavage by two-photon irradiation permitting micropatterning of disulfide-crosslinked networks.
en
dc.language.iso
en
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dc.publisher
RSC
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dc.relation.ispartof
Polymer Chemistry
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dc.rights.uri
http://creativecommons.org/licenses/by/3.0/
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dc.subject
Photopolymerization
en
dc.subject
2-photon polymerization
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dc.subject
photodegradation
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dc.title
A disulfide-based linker for thiol-norbornene conjugation: formation and cleavage of hydrogels by the use of light