<div class="csl-bib-body">
<div class="csl-entry">Schwarzenberger, S. (2015). <i>Pulse wave decomposition and analysis in diabetic patients using Gaussian peak fitting</i> [Master Thesis, Technische Universität Wien]. reposiTUm. https://doi.org/10.34726/hss.2015.29808</div>
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dc.identifier.uri
https://doi.org/10.34726/hss.2015.29808
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dc.identifier.uri
http://hdl.handle.net/20.500.12708/9114
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dc.description
Zsfassung in dt. Sprache
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dc.description.abstract
Diabetes induced complications like peripheral vascular disease (PVD) and neuropathy promote the formation of wounds and lead to impaired wound healing in diabetic patients. Early detection and effective, low cost treatment options are key factors to improve the patient's quality of life as well as to reduce health care costs. New therapeutic approaches like percutaneous auricular vagus nerve stimulation (aVNS) promise to reactivate the autonomous nervous system (ANS), promote wound healing or prevent the formation of new wounds. To monitor the effects of aVNS on the ANS, the pulse plethysmography (PPG) signal of healthy and diabetic patients was recorded and analyzed in the course of a pilot study. Parameters of interest were the systolic-diastolic volume deflection, the reflection time and the reflection index. For the latter two, the respective incident and reflected pulse waves in each cardiac cycle need to be extracted from the PPG signal. This was achieved by Gaussian peak fitting, using an iterative least-square fitting algorithm. The algorithm was validated by the use of artificial and real measured pulse signals. For most regular PPG signals, fitting errors of < 5 % could be achieved. Using appropriate quality control mechanisms, highly automated and accurate analysis is possible. Besides a decomposition of incident and reflected waves, the original PPG signal can also be reconstituted from the Gauss parameters, and thus may help to save memory. The feasibility of analyzing full datasets from the pilot study was tested. In this analysis, differences between single healthy and diabetic patients could be observed. Thus, the presented method holds potential for diagnostics and a possible monitoring of therapeutic effects. Long-term effects were not assessed and further analysis is necessary.
en
dc.language
English
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dc.language.iso
en
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dc.rights.uri
http://rightsstatements.org/vocab/InC/1.0/
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dc.subject
Pulse wave
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dc.subject
diabetis
en
dc.subject
optical plethysmography
en
dc.title
Pulse wave decomposition and analysis in diabetic patients using Gaussian peak fitting
en
dc.type
Thesis
en
dc.type
Hochschulschrift
de
dc.rights.license
In Copyright
en
dc.rights.license
Urheberrechtsschutz
de
dc.identifier.doi
10.34726/hss.2015.29808
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dc.contributor.affiliation
TU Wien, Österreich
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dc.rights.holder
Sebastian Schwarzenberger
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tuw.version
vor
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tuw.thesisinformation
Technische Universität Wien
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dc.contributor.assistant
Kampusch, Stefan
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tuw.publication.orgunit
E354 - Institute of Electrodynamics, Microwave and Circuit Engineering