In this talk we will discuss some challenges on leadership in general and focus on leadership for researchers/scientists at universities in particular. We will address the challenges from a holistic perspective spanning many opportunities which present themselves on a daily basis such as: (change of) mindset, habits for successful leadership, personal well-being, high-performance in teams, individualism and teamwork, amongst others. The goal of this talk will be to tease out relevant aspects regarding (digital) leadership and to jointly reflect on them.