Berger, N., Bärnthaler, T., Gindlhuber, J., Girgis, N., Hirschmugl, B., van der Wel, T., Zimmermann, R., Birner-Grünberger, R., van der Stelt, M., & Wadsack, C. (2021). Placental DAGLβ regulates 2-arachidonoylglycerol (2-AG) levels and is involved in pregnancy induced inflammation. Placenta, 112, e41–e42. https://doi.org/10.1016/j.placenta.2021.07.135
Obstetrics and Gynecology; Developmental Biology; Reproductive Medicine
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Abstract:
Diacylglycerollipase alpha/beta (DAGLα/β) are two sequence-related serine hydrolases, biosynthesizing 2-arachidonoylglycerol (2-AG). 2-AG, one of the main endocannabinoids, and its esterified fatty acid arachidonic acid serve as substrates for pro-inflammatory cellular pathways. Chronic inflammation is one hallmark of placentas affected by preeclampsia (PE) which is often linked to an altered lipid metabolism. In this study, we aim to identify the specific function and regulation of DAGLα/β in healthy (CTRL) and PE placentas.
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Research Areas:
Biological and Bioactive Materials: 80% außerhalb der gesamtuniversitären Forschungsschwerpunkte: 20%