Zandrini, T., Florczak, S., Levato, R., & Ovsianikov, A. (2022). Breaking the resolution limits of 3D bioprinting: future opportunities and present challenges. Trends in Biotechnology. https://doi.org/10.1016/j.tibtech.2022.10.009
E308-02-3 - Forschungsgruppe 3D Printing and Biofabrication
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Journal:
Trends in Biotechnology
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ISSN:
0167-7799
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Date (published):
10-Dec-2022
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Publisher:
ELSEVIER SCIENCE LONDON
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Peer reviewed:
Yes
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Keywords:
HD bioprinting; biofabrication; organ-on-a-chip; multiphoton lithography; cell electrowriting; volumeter printing; digital light processing
en
Abstract:
Bioprinting aims to produce 3D structures from which embedded cells can receive mechanical and chemical stimuli that influence their behavior, direct their organization and migration, and promote differentiation, in a similar way to what happens within the native extracellular matrix. However, limited spatial resolution has been a bottleneck for conventional 3D bioprinting approaches. Reproducing fine features at the cellular scale, while maintaining a reasonable printing volume, is necessary to enable the biofabrication of more complex and functional tissue and organ models. In this opinion article we recount the emergence of, and discuss the most promising, high-definition (HD) bioprinting techniques to achieve this goal, discussing which obstacles remain to be overcome, and which applications are envisioned in the tissue engineering field.
