Suchy, L., & Rudroff, F. (2021). Multi-Enzymatic Cascades In Vivo. In S. Kara & F. Rudroff (Eds.), Enzyme Cascade Design and Modelling (pp. 49–63). Springer. https://doi.org/10.1007/978-3-030-65718-5_4
In vivo biotransformations; Biocatalysis; Enzymatic cascade reactions; Whole-cell biocatalysis; Artificial metabolic pathways
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Abstract:
An immense number of chemical reactions are carried out simultaneously in living cells. Nature tackles the complexity by cascading assemblies of reactions in finely tuned metabolic networks. Multistep cascades in living organisms commonly function without separation of intermediates; concentrations of all reactants are kept low, which allows high selectivity and avoids by-product formation. Taking Nature as a model, application of cascade reactions in organic synthesis offers several advantages over the classical step-by-step approach. In this chapter, pros and cons of enzymatic cascades in living cells are described and the current status of the design and the application of them are highlighted.
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Research Areas:
Biological and Bioactive Materials: 50% Sustainable Production and Technologies: 50%
