Record link: 
http://hdl.handle.net/20.500.12708/144646
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Title: 
Design and Synthesis of Novel Deuterated Ligands Functionally Selective for the γ‑Aminobutyric Acid Type A Receptor (GABAAR) α6 Subtype with Improved Metabolic Stability and Enhanced Bioavailability
en
Citation: 
Knutson, D. E., Kodali, R., Divović, B., Treven, M., Stephen, M. R., Zahn, N. M., Dobričić, V., Huber, A. T., Meirelles, M. A., Verma, R. S., Wimmer, L., Witzigmann, C., Arnold, L. A., Ciou, L.-C., Ernst, M., Mihovilovic, M. D., Savic, M. M., Sieghart, W., & Cook, J. M. (2018). Design and Synthesis of Novel Deuterated Ligands Functionally Selective for the γ‑Aminobutyric Acid Type A Receptor (GABAAR) α6 Subtype with Improved Metabolic Stability and Enhanced Bioavailability. Journal of Medicinal Chemistry, 61(6), 2422–2446. https://doi.org/10.1021/acs.jmedchem.7b01664
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Publisher DOI: 
10.1021/acs.jmedchem.7b01664
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Publication Type: 
Article - Original Research Article
en
Language: 
English
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Authors: 
Knutson, Daniel E. 
Kodali, Revathi 
Divović, Branka 
Treven, Marco 
Stephen, Michael R. 
Zahn, Nicolas M. 
Dobričić, Vladimir 
Huber, Alec T. 
Meirelles, Matheus A. 
Verma, Ranjit S. 
Wimmer, Laurin 
Witzigmann, Christpher 
Arnold, Leggy A. 
Ciou, Lih-Chu 
Ernst, Margot 
Mihovilovic, Marko D. 
Savic, Miroslav M. 
Sieghart, Werner 
Cook, James M. 
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Organisational Unit: 
E163-03-4 - Forschungsgruppe Bioorganische Synthesechemie 
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Journal: 
Journal of Medicinal Chemistry 
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ISSN: 
0022-2623
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Date (published): 
2018
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Number of Pages: 
25
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Peer reviewed: 
Yes
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Keywords: 
Drug Discovery; Molecular Medicine
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Research Areas: 
außerhalb der gesamtuniversitären Forschungsschwerpunkte: 100%
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Science Branch: 
Chemie
Pharmazie, Pharmakologie, Toxikologie
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