Record link: 
http://hdl.handle.net/20.500.12708/146103
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Title: 
Unambiguous identification and characterization of a long‐term human metabolite of dehydrochloromethyltestosterone
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Citation: 
Forsdahl, G., Geisendorfer, T., Göschl, L., Pfeffer, S., Gärtner, P., Thevis, M., & Gmeiner, G. (2018). Unambiguous identification and characterization of a long‐term human metabolite of dehydrochloromethyltestosterone. Drug Testing and Analysis, 10(8), 1244–1250. https://doi.org/10.1002/dta.2385
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Publisher DOI: 
10.1002/dta.2385
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Publication Type: 
Article - Original Research Article
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Language: 
English
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Authors: 
Forsdahl, Guro 
Geisendorfer, Thomas 
Göschl, Lorenz 
Pfeffer, Sandra 
Gärtner, Peter 
Thevis, Mario 
Gmeiner, Günter 
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Organisational Unit: 
E163-03-3 - Forschungsgruppe Stereoselektive und nachhaltige Chemie 
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Journal: 
Drug Testing and Analysis 
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ISSN: 
1942-7603
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Date (published): 
23-Mar-2018
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Number of Pages: 
7
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Publisher: 
WILEY
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Peer reviewed: 
Yes
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Keywords: 
Pharmaceutical Science; Environmental Chemistry; Spectroscopy; Analytical Chemistry
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Abstract: 
In doping control analysis, the characterization of urinary steroid metabolites is of high interest for a targeted and long-term detection of prohibited anabolic androgenic steroids (AAS). In this work, the structure of a long-term metabolite of dehydrochloromethyltestosterone (DHCMT) was elucidated. Altogether, 8 possible metabolites with a 17α-methyl-17β-hydroxymethyl – structures were synthesized and compared to a major DHCMT long-term metabolite detected in reference urine excretion samples. The confirmed structure of the metabolite was 4α-chloro-18-nor-17β-hydroxymethyl-17α-methyl-5α-androst-13-en-3α-ol.
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Research Areas: 
Biological and Bioactive Materials: 100%
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Science Branch: 
Chemie
Chemische Verfahrenstechnik
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