Zimmermann, C., Till, P., Danner, C., & Mach-Aigner, A. R. (2022). Genetic Regulation Networks in Cellulase and Hemicellulase Production in an Industrially Applied Cellulase Producer Trichoderma reesei. In V. Bisaria (Ed.), Handbook of Biorefinery Research and Technology. Springer. https://doi.org/10.1007/978-94-007-6724-9_25-1
Due to its natural lifestyle as a saprotroph, Trichoderma reesei is a potent producer of enzymes involved in the degradation of plant biomass, in particular cellulases and hemicellulases. As such, T. reesei has become a microorganism used in industry for the production of these enzymes. In this chapter, the so far known regulatory mechanisms that have an important impact on the expression of
cellulases and hemicellulases in T. reesei are described. In this regard, classical
gene regulation, for example, by carbon catabolite repression or transcriptional
activation, and the respective transcription factors, such as Cre1, Xyr1, or Ace3,
are summarized. Also, the reported epigenetic regulatory mechanisms ranging
from DNA methylation to histone modification and chromatin accessibility to
regulatory noncoding RNAs, such as HAX1, are discussed.
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Research Areas:
Sustainable Production and Technologies: 50% Efficient Utilisation of Material Resources: 50%
