In recent years, several studies evaluated the potential of different antioxidant additives to improve the ageing resistance of asphalt binders, therefore, improving the durability of asphalt pavements. Among the evaluated antioxidant additives, the combination of Furfural with Dilauryl thiodipropionate (DLTDP) was shown to be a promising alternative to reduce the extent of oxidative aging of asphalt binders. This study investigates the effect of this promising antioxidant compound on the fatigue performance of asphalt binders. The Linear Amplitude Sweep (LAS) test was conducted on long-term aged (PAV) samples of two unmodified 70/100 penetration graded base asphalt binders (control) and their respective modified asphalt binders. The modified asphalt binders were obtained by mixing a given base asphalt binder with a specific percentage of the antioxidant compounds. The results showed that the addition of antioxidant compounds slowed down the loss of integrity of the material under a given damage intensity, for both base asphalt binders. Also, the modified asphalt binders presented lower values of peak shear stress and higher values of shear strain at peak compared with their respective base binders. Therefore, it can be hypothesized that modified asphalt binders are less brittle and less prone to fatigue than the control binders. In general, it was observed that the addition of the antioxidant compound improved the resistance of the asphalt binders to fatigue cracking.