Socially vulnerable population groups have been detected to be much more exposed than others to the covid-19 pandemic. The health crisis unmasked one of the main structural contradictions of neoliberal urbanism, the dichotomy between the ideology of a post-political society based on supposed democratic equality and the actual neoliberal local policies that intensify progressive social displacement, urban marginalization, and uneven geographical development. This contribution aims to analyze spaces of insurgent citizenship deriving from the needs of the lived experience, which affirm the political nature, contingent and radically antagonistic, of disruptive practices reconfiguring established spatial orders while claiming civil and human rights. The cases of Italian Centri Sociali Occupati Autogestiti (CSOA), Self-managed Occupied Social Centers, and Spazi Liberati, Liberated Spaces, have been defining new alternative ways of opposition to neoliberal marginalization that do not necessarily need to be based on grassroots militancy. Indeed, many of these Social Spaces build their social and spatial self-governance strategy on affective networks, relationships of reciprocity, and the provisioning of essential services to guarantee the right to the city to any subaltern social group, on the base of voluntarily offered resources, material and immaterial ones. Starting from a critical understanding of the local consequences of neoliberal modes of space production, this contribution positions CSOA within the history of the alter-globalization urban social movements, highlighting their transformation into everyday, open, and heterogenous Social Spaces. Then, investigating the case-study of Ex-OPG and the Sant’Antonio a Tarsia Liberata church in Naples, according to a qualitative methodological approach, the paper focuses on the issue of homelessness, to be understood through the intersectionality of all struggles of urban subaltern groups. Moreover, the research draws on the theoretical and practical connections among insurgency, care, and the urban space, proposing the conceptualization of insurgent spaces of care.