Record link: 
http://hdl.handle.net/20.500.12708/166723
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Title: 
Synthesis of glycyrrhetinic acid derivatives for the treatment of metabolic diseases
en
Citation: 
Beseda, I., Czollner, L., Shah, P., Khunt, R., Gaware, R., Kosma, P., Stanetty, C., Ruiz-Ruiz, M. C. del, Amer, H., Mereiter, K., Da Cunha, T., Odermatt, A., Claßen-Houben, D., & Jordis, U. (2010). Synthesis of glycyrrhetinic acid derivatives for the treatment of metabolic diseases. Bioorganic and Medicinal Chemistry, 18(1), 433–454. https://doi.org/10.1016/j.bmc.2009.10.036
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Publisher DOI: 
10.1016/j.bmc.2009.10.036
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Publication Type: 
Article - Original Research Article
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Language: 
English
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Authors: 
Beseda, Igor 
Czollner, Laszlo 
Shah, Priti 
Khunt, Rupesh 
Gaware, Rawindra 
Kosma, Paul 
Stanetty, Christian 
Ruiz-Ruiz, Maria Carmen del 
Amer, Hassan 
Mereiter, Kurt 
Da Cunha, Thierry 
Odermatt, Alex 
Claßen-Houben, Dirk 
Jordis, Ulrich 
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Organisational Unit: 
E164-05-1 - Forschungsgruppe Experimentelle Strukturchemie 
E163-03 - Forschungsbereich Organische und Biologische Chemie 
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Journal: 
Bioorganic and Medicinal Chemistry 
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ISSN: 
0968-0896
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Date (published): 
2010
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Number of Pages: 
22
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Publisher: 
PERGAMON-ELSEVIER SCIENCE LTD
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Peer reviewed: 
Yes
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Keywords: 
Pharmaceutical Science; Biochemistry; Molecular Biology; Drug Discovery; Clinical Biochemistry; Organic Chemistry; Molecular Medicine
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Abstract: 
The effect of glycyrrhetinic acid (GA) and GA-derivatives towards 11b-hydroxysteroid dehydrogenase (11b-HSD) was investigated. Novel compounds with modifications at positions C-3, C-11 and C-29 of the GA skeleton were prepared. Single crystal X-ray diffraction data of selected substances are reported and discussed.
en
Research Areas: 
Biological and Bioactive Materials: 80%
Structure-Property Relationship: 20%
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Science Branch: 
Chemie
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Appears in Collections:
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