<div class="csl-bib-body">
<div class="csl-entry">Rohringer, S., Grasl, C., Ehrmann, K., Hager, P., Hahn, C., Specht, S. J., Walter, I., Schneider, K. H., Zopf, L. M., Baudis, S., Liska, R., Schima, H., Podesser, B., & Bergmeister, H. (2023). Biodegradable, Self-Reinforcing Vascular Grafts for In Situ Tissue Engineering Approaches. <i>Advanced Healthcare Materials</i>, Article 2300520. https://doi.org/10.1002/adhm.202300520</div>
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dc.identifier.issn
2192-2640
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dc.identifier.uri
http://hdl.handle.net/20.500.12708/187814
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dc.description.abstract
Clinically available small-diameter synthetic vascular grafts (SDVGs) have unsatisfactory patency rates due to impaired graft healing. Therefore, autologous implants are still the gold standard for small vessel replacement. Bioresorbable SDVGs may be an alternative, but many polymers have inadequate biomechanical properties that lead to graft failure. To overcome these limitations, a new biodegradable SDVG is developed to ensure safe use until adequate new tissue is formed. SDVGs are electrospun using a polymer blend composed of thermoplastic polyurethane (TPU) and a new self-reinforcing TP(U-urea) (TPUU). Biocompatibility is tested in vitro by cell seeding and hemocompatibility tests. In vivo performance is evaluated in rats over a period for up to six months. Autologous rat aortic implants serve as a control group. Scanning electron microscopy, micro-computed tomography (µCT), histology, and gene expression analyses are applied. TPU/TPUU grafts show significant improvement of biomechanical properties after water incubation and exhibit excellent cyto- and hemocompatibility. All grafts remain patent, and biomechanical properties are sufficient despite wall thinning. No inflammation, aneurysms, intimal hyperplasia, or thrombus formation are observed. Evaluation of graft healing shows similar gene expression profiles of TPU/TPUU and autologous conduits. These new biodegradable, self-reinforcing SDVGs may be promising candidates for clinical use in the future.
en
dc.language.iso
en
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dc.publisher
Wiley
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dc.relation.ispartof
Advanced Healthcare Materials
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dc.rights.uri
http://creativecommons.org/licenses/by-nc-nd/4.0/
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dc.subject
biodegradables
en
dc.subject
self-reinforcing
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dc.subject
small diameter vascular grafts
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dc.subject
tissue engineering
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dc.title
Biodegradable, Self-Reinforcing Vascular Grafts for In Situ Tissue Engineering Approaches
en
dc.type
Article
en
dc.type
Artikel
de
dc.rights.license
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
en
dc.rights.license
Creative Commons Namensnennung - Nicht kommerziell - Keine Bearbeitungen 4.0 International