<div class="csl-bib-body">
<div class="csl-entry">Iglseder, S., Iglseder, A., Beliveau, V., Heugenhauser, J., Gizewski, E. R., Kerschbaumer, J., Stockhammer, G., Uprimny, C., Virgolini, I., Dudas, J., Nevinny-Stickel, M., Nowosielski, M., & Scherfler, C. (2023). Somatostatin receptor subtype expression and radiomics from DWI-MRI represent SUV of [68Ga]Ga-DOTATOC PET in patients with meningioma. <i>Journal of Neuro-Oncology</i>, <i>164</i>(2), 711–720. https://doi.org/10.1007/s11060-023-04414-3</div>
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dc.identifier.issn
0167-594X
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dc.identifier.uri
http://hdl.handle.net/20.500.12708/189330
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dc.description.abstract
This retrospective study aimed to analyse the correlation between somatostatin receptor subtypes (SSTR 1–5) and maximum standardized uptake value (SUVmax) in meningioma patients using Gallium-68 DOTA-D-Phe1-Tyr3-octreotide Positron Emission Tomography ([68Ga]Ga-DOTATOC PET). Secondly, we developed a radiomic model based on apparent diffusion coefficient (ADC) maps derived from diffusion weighted magnetic resonance images (DWI MRI) to reproduce SUVmax.
The study included 51 patients who underwent MRI and [68Ga]Ga-DOTATOC PET before meningioma surgery. SUVmax values were quantified from PET images and tumour areas were segmented on post-contrast T1-weighted MRI and mapped to ADC maps. A total of 1940 radiomic features were extracted from the tumour area on each ADC map. A random forest regression model was trained to predict SUVmax and the model’s performance was evaluated using repeated nested cross-validation. The expression of SSTR subtypes was quantified in 18 surgical specimens and compared to SUVmax values.
The random forest regression model successfully predicted SUVmax values with a significant correlation observed in all 100 repeats (p < 0.05). The mean Pearson’s r was 0.42 ± 0.07 SD, and the root mean square error (RMSE) was 28.46 ± 0.16. SSTR subtypes 2A, 2B, and 5 showed significant correlations with SUVmax values (p < 0.001, R2 = 0.669; p = 0.001, R2 = 0.393; and p = 0.012, R2 = 0.235, respectively).
SSTR subtypes 2A, 2B, and 5 correlated significantly with SUVmax in meningioma patients. The developed radiomic model based on ADC maps effectively reproduces SUVmax using [68Ga]Ga-DOTATOC PET.
en
dc.language.iso
en
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dc.publisher
Springer Nature
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dc.relation.ispartof
Journal of Neuro-Oncology
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dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
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dc.subject
ADC maps
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dc.subject
Radiometric features
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dc.subject
SUVmax
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dc.subject
[68Ga]Ga-DOTATOC PET
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dc.subject
Meningioma
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dc.title
Somatostatin receptor subtype expression and radiomics from DWI-MRI represent SUV of [68Ga]Ga-DOTATOC PET in patients with meningioma