Modern distributed systems also deal with uncertain scenarios where environments, infrastructures, and applications are widely diverse. In the scope of IoT-Edge-Fog-Cloud computing, leveraging these neuroscience-inspired principles and mechanisms could aid in building more flexible solutions able to generalize over different environments. A captivating set of hypotheses from the field of neuroscience suggests that human and animal brain mechanisms result from few powerful principles. If proved to be accurate, these assumptions could open a deep understanding of the way humans and animals manage to cope with the unpredictability of events and imagination.