This paper introduces a novel population‐based bio‐inspired meta‐heuristic optimization algorithm, called Blood Coagulation Algorithm (BCA). BCA derives inspiration from the process of blood coagulation in the human body. The underlying concepts and ideas behind the proposed algorithm are the cooperative behavior of thrombocytes and their intelligent strategy of clot formation. These behaviors are modeled and utilized to underscore intensification and diversification in a given search space. A comparison with various state‐of‐the‐art meta‐heuristic algorithms over a test suite of 23 renowned benchmark functions reflects the efficiency of BCA. An extensive investigation is conducted to analyze the performance, convergence behavior and computational complexity of BCA. The comparative study and statistical test analysis demonstrate that BCA offers very competitive and statistically significant results compared to other eminent meta‐heuristic algorithms. Experimental results also show the consistent performance of BCA in high dimensional search spaces. Furthermore, we demonstrate the applicability of BCA on real‐world applications by solving several real‐life engineering problems.