Electron spin resonance is a widely used analytical tool in medicine, biology and material sciences. Traditionally, electron spin systems are driven by microwaves, which offers only limited spatial resolution due to the long wavelength of microwaves, which can be optimized by sophisticated techniques such as the use of magnetic field gradients. We propose a different way of driving spin systems using the non-radiative near-field of a modulated electron beam in a scanning electron microscope by tuning the microscopes to higher beam currents and using additional beam modulation mechanisms. Driving systems with higher harmonics of the modulated beam opens up future possibilities to perform in-situ electron spin resonance analysis with high spatial resolution down to the nanoscale. To perform our experiments we modified an Philips XL30 ESEM to allow for high frequency beam modulation, cryogenic cooling of our samples and microwave frequency readout of our spin systems.