Record link: 
http://hdl.handle.net/20.500.12708/216707
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Title: 
In-vitro Hemocompatibility Evaluation of the HeartMate 3 under Realistic Operating Conditions
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Citation: 
He, X., Narayanaswamy, K., Fischer, M. B., Schmitt, L., Ruthmeier, T., Messner, B., Jakubek, S., Zimpfer, D., & Granegger, M. (2025). In-vitro Hemocompatibility Evaluation of the HeartMate 3 under Realistic Operating Conditions. IEEE Transactions on Biomedical Engineering. https://doi.org/10.1109/TBME.2025.3560187
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Publisher DOI: 
10.1109/TBME.2025.3560187
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Publication Type: 
Article - Original Research Article
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Language: 
English
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Authors: 
He, Xiangyu 
Narayanaswamy, Krishnaraj 
Fischer, Michael B 
Schmitt, Leonie 
Ruthmeier, Teresa 
Messner, Barbara 
Jakubek, Stefan 
Zimpfer, Daniel 
Granegger, Marcus 
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Organisational Unit: 
E325-04 - Forschungsbereich Regelungstechnik und Prozessautomatisierung 
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Journal: 
IEEE Transactions on Biomedical Engineering 
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ISSN: 
0018-9294
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Date (published): 
11-Apr-2025
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Number of Pages: 
7
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Publisher: 
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
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Peer reviewed: 
Yes
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Keywords: 
Rotary blood pumps; hemocompatibility; pulsatility; realistic operating conditions
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Abstract: 
Operating conditions significantly influence hemolysis generation in rotodynamic blood pumps (RBPs). Previous experiments conducted under constant operating conditions have demonstrated that lower flow rates are associated with a higher normalized index of hemolysis (NIH). However, in clinical scenarios, the pump flow rate fluctuates in response to the residual cardiac function. This study aims to investigate the effects of various pulsatile operating conditions on hemolysis generation and von Willebrand Factor (vWF) degradation of RBP.
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Project (external): 
This work was funded by the Austrian Federal Ministry of Labor and Economy, the National Foundation for Research, Technology and Development and the Christian Doppler Research Association. (Corresponding author: Marcus Granegger, PhD) ( Email: marcus.granegger@meduniwien.ac.at)
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Research Areas: 
Biological and Bioactive Materials: 30%
Modeling and Simulation: 30%
Computational System Design: 40%
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Science Branch: 
2060 - Medizintechnik: 50%
2030 - Maschinenbau: 25%
3040 - Medizinische Biotechnologie: 25%
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