Advances in Mechanochemical C─H Functionalization: A Comparative Study with Solvent‐Based Approaches

Abstract

This review provides an overview on recent progress in mechanochemical transition metal catalyzed C─H functionalization. Solventless operation and enhanced reaction efficiency makes mechanochemical synthesis a more sustainable alternative to conventional approaches. By including a comparison between mechanochemical methods and conventional solvent-based protocols, this review provides chemists with valuable insights into the relative efficiency and sustainability of these solventless strategies. This comparison enables informed decision-making when selecting methods for C─H functionalization based on specific needs. Moreover, the review identifies existing gaps in mechanochemical C─H functionalization and discusses necessary steps to establish it as a mainstream approach. By bridging these gaps, chemists can further enhance the utility and adoption of mechanochemical methodologies, contributing to more sustainable practices in synthetic chemistry.