Schnürch, M. (2025, June 17). „The best solvent is no solvent – exploring the potential of mechanochemical organic synthesis” [Presentation]. TCH Science Days 2025 – Faculty of Technical Chemistry, Wien, Austria.
In recent years, mechanochemistry has revived as an important method in modern synthetic chemistry.[1] Especially en route to more sustainable and environmentally benign chemical processes, mechanochemical transformations are privileged,[2] since this approach offers important advantages: the ability to conduct conventional synthetic reactions without the need for solvents coupled with rapid reaction kinetics. These unique features make mechanochemistry highly attractive for both industrial applications and fundamental research across diverse fields, including material science, inorganic chemistry, and organic chemistry.
Hence, we started a program to investigate the possibilities for carrying out fundamental organic transformations under solvent free conditions using a mechanochemical setup. Herein we report our results on mechanochemical Tsuji-Trost allylations,[3] Wittig reactions,[4] C(sp3)-H functionalization,[5] and Diels-Alder reactions as well as multistep sequences thereof.
1 J. L. Howard, Q. Cao, D. L. Browne, Chemical Science 2018, 9, 3080.
2 E. Colacino, F. Garcia, Mechanochemistry and Emerging Technologies for Sustainable Chemical Manufacturing, CRC Press, 2023, ISBN: 1000891623, 9781000891621
3 J. Templ, M. Schnürch, Angew. Chem. Int. Ed. 2024, 63, e202314637
4 J. Templ, M. Schnürch, Angew. Chem. Int. Ed. 2024, 63, e202411536.
5 N. K. Narayanan, M. Schnürch, ChemCatChem 2024, 0, e202401613
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Research facilities:
Röntgenzentrum Zentrum für Kernspinresonanzspektroskopie
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Project title:
C-H Activation Towards Industrial Renewal: 860762 (European Commission) Substitution von gasförmigen Reagenzien durch Feststoffe: P 33064-N (FWF - Österr. Wissenschaftsfonds)
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Research Areas:
Efficient Utilisation of Material Resources: 30% Beyond TUW-research focus: 70%
