Coherent control and detection of quantum systems are central to quantum technologies. Beyond excitation with optical and microwave fields, free-space electrons can be used to manipulate and detect quantum systems with unique spatial and spectroscopic resolution. In this talk, I outline the theoretical framework [1, 2] showing that the non-radiative near-field of a spatially modulated electron beam can coherently drive quantum systems and show preliminary experimental data [3]. I then present our SPINEM (Spin Electron Microscopy) platform [4], which integrates continuous-wave electron spin resonance (ESR) spectroscopy into a transmission electron microscope (TEM). Using a miniaturized microwave resonator with the free-space electrons of a TEM [5], we enable in-situ, phase-locked detection of microwave-driven spin precession with picoradian deflection sensitivity (<300 prad) for localized spin spectroscopy. Finally, I discuss a roadmap toward magnetic resonance imaging (MRI) with aloof electrons, enabling magnetic resonance studies with reduced radiation damage. I will present estimates indicating a path toward atomic spatial resolution and single- spin sensitivity [6], opening new opportunities in nanoscale spintronics, magnonics, quantum materials, and quantum technologies.