Introduction Digital light processing stereolithography (DLP-SLA) provides the opportunity to manufacture biocompatible patient specific materials for bone tissue engineering approaches. Highly crosslinked state of the art materials based on (meth)acrylate resins cannot meet the high requirements concerning mechanical properties and biocompatibility. Novel vinyl ester (VE) monomer systems enable precisely manufactured customized scaffolds for bone tissue regeneration. Methods VE-based systems were investigated and compared to (meth)acrylate benchmark systems.[1] Thiol-ene chemistry, new synthesized VE's and additives were established to increase reactivity and mechanical properties, especially thoughness.[2,3] The properties of the photopolymers were analyzed by photorheology, mechanical tests and degradation experiments.[3] Results Thiol-ene chemistry demonstrated to be a suitable tool to increase resin reactivity and improve the mechanical performance of the photopolymers due to its network regulation capabilities. In order to use DLP-SLA as advanced 3D printing technique a defined inner and outer structure can be constructed. Preliminary in vivo studies with these scaffolds over 12 weeks showed no inflammation, ongoing biodegradation and excellent vascularization. Discussion and Conclusions Tough 3D printable scaffolds based on VE polymers are well suited as screwable implants for bone tissue regeneration with excellent biocompatibility and biodegradation behavior. References [1] Thiol-ene photopolymerization for efficient curing of vinyl esters, J. Polym. Sci. A, 51, 2013, 203-212 [2] Tough photopolymers based on vinyl esters for biomedical applications, J. Polym. Sci. A, 54, 2016, 1987-1997 [3] Toughness enhancers for bone scaffold materials based on biocompatible photopolymers, J. Polym. Sci. A, 57, 2019, 110-119