Title: Creating universality for cancer gene therapy in applying Adenovirus vectors with altered tropism : designing Adenovirus particles using K-Coil/E-Coil technology to control receptor specificity
Language: English
Authors: Kastberger, Birgit 
Qualification level: Diploma
Advisor: Gilbert, Rénald 
Assisting Advisor: Kubicek, Peter Christian
Gadek-Wesierski, Jozefa 
Issue Date: 2011
Number of Pages: 91
Qualification level: Diploma
Abstract: 
For my Master Thesis project I was charged with the design of two recombinant types of adenoviruses. The first adenovirus should possess a K-coil sequence situated in the HI-loop region of the fibre's knob domain, the other one was supposed to have an ablated CAR tropism in addition to the identical K-coil insertion. The virus' transduction efficiency via EGF-receptors was monitored by fluorescents provoked by a GFP marker, that had to be inserted into the E1 region of the AdV genome for this reason.
Keywords: Adenovirus; Gentherapie; K-Coil; E-Coil Technologie; Krebs; Biotechnologie; Tropismus; Car-Rezeptor; GFP-Marker
Adenovirus; Gene therapy; K-Coil; E-Coil Technology; Cancer; Biotechnology; Tropism; Car-Receptor; GFP-Marker
URI: https://resolver.obvsg.at/urn:nbn:at:at-ubtuw:1-42163
http://hdl.handle.net/20.500.12708/12301
Library ID: AC07809229
Organisation: E166 - Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften 
Publication Type: Thesis
Hochschulschrift
Appears in Collections:Thesis

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