In order to comply with the European’s Green Deal ambition of a climate neutral energy sector by 2050 and to reach the decarbonization goals of the Paris Agreement, the transition from fossil fuels to renewable energies and biomass-based products must become a reality. Anaerobic digestion has been gaining popularity in the last decades for the production of biogas from organic waste, agricultural waste, and energy crops. Biogas is a mixture of approximately 70 % methane, 29 % carbon dioxide, and 1 % other gases. Biogas plants produce electrical and thermal energy by burning the biogas in combined heat and power units. The obtained biogas can also be upgraded into a 95 % to 99 % pure biomethane, which can be injected into the grid or used as transport fuel. The anaerobic digestion process can be modelled with the International Water Agency’s (IWA) Anaerobic Digestion Model 1 (ADM1) developed by Batstone et al in 2002. The ADM1, once calibrated, it can be used to predict the system’s performance, biogas production, pH and volatile fatty acid values. The ADM1 has been used to model mono-digestion of different substrates and co-digestion of dairy manure with energy crops, swine manure with glycerol, among others. Co-digestion can be defined as the mixing of wastes or other feedstocks for anaerobic digestion. In this study a modified ADM1 model is used to model the co-digestion of nopal cladodes (prickly pear) with dairy manure, swine manure and chicken manure. Nopal cladodes have proven to be effective to mitigate the effects of climate change and desertification for their crassulacean acid metabolism which helps them endure long droughts. Studies have shown that a hectare of 5-year-old prickly pears can produce 100 tons of fresh cladodes per year in low rainfall areas. The cultivated area nopal cladodes reported in 2015 in Brazil was 600,000 hectares, Tunisia 600,000 hectares, Mexico 230,000 hectares, Morocco 150,000 hectares, Algeria 150,000 hectares and Italy (Sicily) 8,300 hectares. While the wild availability in Mexico and Brazil are 3 million hectares and 0.9 million hectares respectively. The prickly pears from cladodes are known for their significant amounts of pectin. The byproducts that can be extracted through biorefinery technologies from this fruit are galactose, uronic acids and oxalic acids. There are currently two biogas plants running on co-digestion of nopal cladodes with cow manure. No previous studies have been found in literature comparing the biogas yield of different animal manures co-digestated with nopal cladodes.