The pentose phosphate pathway in industrially relevant fungi: crucial insights for bioprocessing

Masi, Audrey; Mach, Robert L.; Mach-Aigner, Astrid R.

doi:10.1007/s00253-021-11314-x

Record link:

http://hdl.handle.net/20.500.12708/137639

Title:

The pentose phosphate pathway in industrially relevant fungi: crucial insights for bioprocessing

Citation:

Masi, A., Mach, R. L., & Mach-Aigner, A. R. (2021). The pentose phosphate pathway in industrially relevant fungi: crucial insights for bioprocessing. Applied Microbiology and Biotechnology, 105(10), 4017–4031. https://doi.org/10.1007/s00253-021-11314-x

Publisher DOI:

10.1007/s00253-021-11314-x

CatalogPlus:

AC17202383

Publication Type:

Article - Original Research Article

Language:

English

Authors:

Masi, Audrey
Mach, Robert L.
Mach-Aigner, Astrid R.

Organisational Unit:

E166-05-1 - Forschungsgruppe Synthetische Biologie und Molekulare Biotechnologie

Journal:

Applied Microbiology and Biotechnology

ISSN:

0175-7598

Date (published):

May-2021

Number of Pages:

Publisher:

SPRINGER

Peer reviewed:

Yes

Keywords:

General Medicine; Biotechnology; Applied Microbiology and Biotechnology

Abstract:

The pentose phosphate pathway (PPP) is one of the most targeted pathways in metabolic engineering. This pathway is the primary source of NADPH, and it contributes in fungi to the production of many compounds of interest such as polyols, biofuels, carotenoids, or antibiotics. However, the regulatory mechanisms of the PPP are still not fully known. This review provides an insight into the current comprehension of the PPP in fungi and the limitations of this current understanding. It highlights how this knowledge contributes to targeted engineering of the PPP and thus to better performance of industrially used fungal strains.

Research Areas:

Efficient Utilisation of Material Resources: 50%
Sustainable Production and Technologies: 50%

Science Branch:

Chemische Verfahrenstechnik

License:

CC BY 4.0