Title: Intrinsically Magnetic Cells: A Review on Their Natural Occurrence and Synthetic Generation
Authors: Pekarsky, Alexander 
Spadiut, Oliver 
Category: Review Article
Issue Date: 19-Oct-2020
Journal: Frontiers in Bioengineering and Biotechnology 
ISSN: 2296-4185
Abstract: 
The magnetization of non-magnetic cells has great potential to aid various processes in medicine, but also in bioprocess engineering. Current approaches to magnetize cells with magnetic nanoparticles (MNPs) require cellular uptake or adsorption through in vitro manipulation of cells. A relatively new field of research is "magnetogenetics" which focuses on in vivo production and accumulation of magnetic material. Natural intrinsically magnetic cells (IMCs) produce intracellular, MNPs, and are called magnetotactic bacteria (MTB). In recent years, researchers have unraveled function and structure of numerous proteins from MTB. Furthermore, protein engineering studies on such MTB proteins and other potentially magnetic proteins, like ferritins, highlight that in vivo magnetization of non-magnetic hosts is a thriving field of research. This review summarizes current knowledge on recombinant IMC generation and highlights future steps that can be taken to succeed in transforming non-magnetic cells to IMCs.
Keywords: continuous cultivation; encpasulin; ferritin; intrinsic magnetism; magnetic cells; magnetic protein; magnetotactic bacteria
DOI: 10.3389/fbioe.2020.573183
Organisation: E166-04-2 - Forschungsgruppe Integrierte Bioprozessentwicklung 
License: CC BY 4.0 CC BY 4.0
Publication Type: Article
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