Preparation of Nonradioactive Standards and a Precursor for a Hypoxia ¹⁸F PET Tracer Derived from 1-(β-d-Galactopyranosyl)-2-nitroimidazole

Abstract

Acetyl-protected 1-(β- d -galactopyranosyl)-2-nitroimidazole was converted to a potential precursor for a fluorine-18 labeled hypoxia tumor marker. Two nonradioactive standards, the 6′-deoxy-6′-fluorogalactosyl and the 4′-deoxy-4′-fluoroglucosyl analogue were also prepared. These 2-nitroimidazole nucleosides were prepared by a modified Vorbrüggen coupling.