Record link: 
http://hdl.handle.net/20.500.12708/190893
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Title: 
Preparation of Nonradioactive Standards and a Precursor for a Hypoxia ¹⁸F PET Tracer Derived from 1-(β-d-Galactopyranosyl)-2-nitroimidazole
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Citation: 
Schweifer, A., Malová Križková, P., Mereiter, K., & Hammerschmidt, F. (2017). Preparation of Nonradioactive Standards and a Precursor for a Hypoxia 18F PET Tracer Derived from 1-(β-d-Galactopyranosyl)-2-nitroimidazole. Synthesis: Journal of Synthetic Organic Chemistry, 49(13), 2933–2938. https://doi.org/10.1055/s-0036-1588991
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Publisher DOI: 
10.1055/s-0036-1588991
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Publication Type: 
Article - Original Research Article
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Language: 
English
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Authors: 
Schweifer, Anna 
Malová Križková, Petra 
Mereiter, Kurt 
Hammerschmidt, Friedrich 
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Organisational Unit: 
E164 - Institut für Chemische Technologien und Analytik 
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Journal: 
Synthesis: Journal of Synthetic Organic Chemistry 
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ISSN: 
0039-7881
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Date (published): 
2017
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Number of Pages: 
6
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Publisher: 
GEORG THIEME VERLAG KG
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Peer reviewed: 
Yes
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Keywords: 
2-nitroimidazole; d-galactose; d-glucose; nucleosides; precursor; tumor hypoxia; [ F]fluoride 18
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Abstract: 
Acetyl-protected 1-(β- d -galactopyranosyl)-2-nitroimidazole was converted to a potential precursor for a fluorine-18 labeled hypoxia tumor marker. Two nonradioactive standards, the 6′-deoxy-6′-fluorogalactosyl and the 4′-deoxy-4′-fluoroglucosyl analogue were also prepared. These 2-nitroimidazole nucleosides were prepared by a modified Vorbrüggen coupling.
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Research facilities: 
Röntgenzentrum 
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Research Areas: 
Materials Characterization: 50%
Non-metallic Materials: 50%
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Science Branch: 
1040 - Chemie: 100%
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