Nanoimprinted hierarchical micro-/nanostructured substrates for the growth of cardiomyocyte fibers

Mühlberger, Michael M.; Kopp, Sonja; Deyett, Alison A.; Pribyl, Markus; Haslinger, Michael J.; Siegel, Anica M.; Taus, Philipp; Guillén, Elena; Torres-Caballero, Aranxa; Baltov, Bozhidar; Netzer, Michael A.; Prado Lopez, Sonia; Yde, Leif; Stensborg, Jan; Mendjan, Sasha; Hering, Steffen; Wanzenböck, Heinz

doi:10.3390/nanomanufacturing3040026

Record link:

http://hdl.handle.net/20.500.12708/191002

Title:

Nanoimprinted hierarchical micro-/nanostructured substrates for the growth of cardiomyocyte fibers

Citation:

Mühlberger, M. M., Kopp, S., Deyett, A. A., Pribyl, M., Haslinger, M. J., Siegel, A. M., Taus, P., Guillén, E., Torres-Caballero, A., Baltov, B., Netzer, M. A., Prado Lopez, S., Yde, L., Stensborg, J., Mendjan, S., Hering, S., & Wanzenböck, H. (2023). Nanoimprinted hierarchical micro-/nanostructured substrates for the growth of cardiomyocyte fibers. Nanomanufacturing, 3(4), 416–433. https://doi.org/10.3390/nanomanufacturing3040026

Publisher DOI:

10.3390/nanomanufacturing3040026

CatalogPlus:

AC17204818

Publication Type:

Article - Original Research Article

Language:

English

Organisational Unit:

E362-02 - Forschungsbereich Nanoelektronische Bauelemente

Journal:

Nanomanufacturing

Date (published):

Dec-2023

Number of Pages:

Publisher:

MDPI

Peer reviewed:

Yes

Keywords:

nanoimprint lithography; cell growth; cardiomyocytes; fiber formation

Abstract:

Investigating the behavior of cardiomyocytes is an important part of drug development. We present a structure and a related nanoimprint-based fabrication method, where the cardiomyocytes form isolated fibers, which is beneficial for drug testing, more closely representing the structure of the cardiomyocytes in vivo. We found that channel structures with walls with a rough top surface stimulate cardiomyocytes to form such fibers, as desired. Nanoimprint lithography is used as a fast and cost-efficient method to fabricate our hierarchically structured cell growth substrates.

Project (external):

FFG (Austrian Research Promotion Agency)
Austrian Science Fund (FWF)

Project ID:

871438
W1232

Research Areas:

Nanoelectronics: 100%

Science Branch:

2020 - Elektrotechnik, Elektronik, Informationstechnik: 100%

License:

CC BY 4.0