Novel pyrazolothienopyridinones as potential GABAA receptor modulators

Vega Alanis, Blanca Angelica; Wimmer, Laurin; Ernst, Margot; Schnürch, Michael; Mihovilovic, Marko D.

doi:10.1007/s00706-023-03063-6

Record link:

http://hdl.handle.net/20.500.12708/191134

Title:

Novel pyrazolothienopyridinones as potential GABAA receptor modulators

Citation:

Vega Alanis, B. A., Wimmer, L., Ernst, M., Schnürch, M., & Mihovilovic, M. D. (2023). Novel pyrazolothienopyridinones as potential GABAA receptor modulators. Monatshefte Für Chemie - Chemical Monthly, 154(12), 1427–1439. https://doi.org/10.1007/s00706-023-03063-6

Publisher DOI:

10.1007/s00706-023-03063-6

CatalogPlus:

AC17204776

Publication Type:

Article - Original Research Article

Language:

English

Authors:

Vega Alanis, Blanca Angelica
Wimmer, Laurin
Ernst, Margot
Schnürch, Michael
Mihovilovic, Marko D.

Organisational Unit:

E163 - Institut für Angewandte Synthesechemie
E163-03 - Forschungsbereich Organische und Biologische Chemie
E163-03-4 - Forschungsgruppe Bioorganische Synthesechemie

Journal:

Monatshefte für Chemie - Chemical Monthly

ISSN:

0026-9247

Date (published):

2023

Number of Pages:

Publisher:

SPRINGER WIEN

Peer reviewed:

Yes

Keywords:

Drug research; Electron-rich heterocyclic amines; GABAA Receptor Modulators; Heterocycles; Scaffold Hopping

Abstract:

The synthesis of novel pyrazolothienopyridinone derivatives as potential GABAA receptor modulators was performed and is herein described. A crucial step of the synthesis involving handling unstable aminothiophenes was managed via two different synthetic strategies delivering a set of 8 target compounds.

Research facilities:

Zentrum für Kernspinresonanzspektroskopie

Project title:

Doktoratskolleg W 1232-B11: DK W1232-B11 (FWF - Österr. Wissenschaftsfonds)

Research Areas:

Biological and Bioactive Materials: 100%

Science Branch:

1040 - Chemie: 80%
3012 - Pharmazie, Pharmakologie, Toxikologie: 20%

License:

CC BY 4.0