Templ, J., & Schnürch, M. (2023, July 11). Mashing up Tsuji-Trost Reaction - A mechanochemical approach [Poster Presentation]. 22nd European Symposium on Organic Chemistry 2023, Ghent, Belgium.
A mechanochemical, solvent-free protocol for Tsuji–Trost allylation of O-, N-, and C-Nucleophiles using nontoxic, solid allyl trimethylammonium chloride as alternative allylating agent is presented. This method features fast reaction kinetics, very low catalyst loadings, high yields, mild conditions, and high functional group tolerance. Its potential for late-stage modifications of bioactive compounds is demonstrated through multiple examples.
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Project title:
Substitution von gasförmigen Reagenzien durch Feststoffe: P 33064-N (FWF - Österr. Wissenschaftsfonds)
